Result: In subtype B one cluster with NNRTI K101H/E138A mutation was observed, in four sequence pairs there was also evidence of the shared resistance patterns (NRTI: D67N/K291Q and T215V, NNRTI: V106I, integrase: E157Q).
Discussion: On the other hand, frequency of the V106I variant, which may be affecting doravirine susceptibility was higher (4.4%) than in reference data (0.8%) from Italy and France published by Soulie et al.
High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.
Result: The most frequently detected DRMs were M184I/V (68/82; 82.9%), K70E/R (16/82; 19.5%), and T215F/Y (17/82; 20.7%) to NRTI and K103N/S (51/82; 62.1%), P225H (15/82; 18.2%), and V106A/I/M (11/82; 13.4%) to NNRTI (Figure 1).
HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China.
Result: Among them, 9 cases were protease inhibitor-related resistance, and the main resistance sites were L33F, V82A, Q58E, M46L, M46I; There were 4 cases of nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V75VI, K219Q, T215A, K65R; There were 5 cases of non-nucleoside reverse transcriptase inhibitor resistance, the main mutation sites were V179E, A98G, V106I, Y181C, G190S
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
Result: The major NNRTI DRMs were V179D/E (37.9%, 149/393), V106I/M (25.7%, 101/393), and K103N/Q (25.2%, 99/393) (Table 3).
Table: V106I/M
Discussion: V106I/M, K103N/Q, G190A/S, and Y181C were the major NNRTI-associated mutations, similar to those in other cities in China and other countries, and showed broad-spectrum resistance possibly caused by the wide use of NNRTIs.
Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.
Discussion: The most frequent NNRTI-associated SDRM in our study was K103N, while it is V179E and V106I in Southwest China and K103N/S and E138A in Iceland and the south-central United States.
Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.
Discussion: Such mutations that were detected in this study mostly targeted NNRTIs, including K103R/V179D, V106I/V179DE, V106I/F227L, and E138AG/V179DE.
HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.
Result: Given the low prevalence of non-B subtypes in the study population, associations between specific viral subtypes and the presence of polymorphic mutations were not particularly relevant in the context of the study population, e.g., V106I was present in all F1 subtypes; however, only 6/6661 F1 viruses were observed, while V106IM (generally combined with other NNRTI mutations) was observed in 231/6577 (3.5%) subtype B viruses.
Result: However, other polymorphic non-SDRMs were also frequent (V106I (3.6%), V179DE (7.1%) in RT) (Figure 2b).
Result: The relatively high resistance to doravirine is noteworthy, and was mainly associated with mutations Y188L (4.5%, in most cases combined with V106I
HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.
PMID: 34762770
2021
Journal of the International AIDS Society
Table: V106A/I
Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China.
Abstract: The most prevalent shared DRMs included V106I (45.35%), V179D (15.1%), and V179E (15.1%).
Result: In particular, two TCs contained shared DRMs of E138G + V179E and V106I + V179D in Baise and Qinzhou cities, respectively.
Result: The largest PDR-related cluster within network contained DRM propagation of E138A, V82VF, V179D, V179VD
Discussion: Sharing of specific DRMs (such as V106I and V179D/E) was frequent within networks, revealing the potential for widespread PDR dissemination in the future.
Correlation of HIV-1 drug resistant mutations and virologic failure.
PMID: 34584606
2021
The Pan African medical journal
HIV mutation literature information.
PMID: 
2021
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