Result: In the case of NVP and EFV resistance, K103N, V106A, V108I, Y181C/L, G190A, P225H, and M230L mutations were detected in more than half of patients after 6.0 months of ART (blue bars in.
Table: V106A
Simultaneous detection of major drug resistance mutations in the protease and reverse transcriptase genes for HIV-1 subtype C by use of a multiplex allele-specific assay.
PMID: 23985909
2013
Journal of clinical microbiology
Abstract: All the wild-type and mutant alleles were unequivocally distinguished with plasmid templates, and the limits of detection were 1.56% for K219Q and K219E, 3.13% for L76V, 6.25% for K65R, K70R, L74V, L100I, K103N, K103R, Q151M, Y181C, and I47V, and 12.5% for M41L, K101P, K101E, V106A, V106M, Y115F, M184V, PMID: 24009694
2013
PloS one
Abstract: Mutations such as M184V/I, K103N, V106A, Y181C and G190A were common among the ART-failure individuals, and the frequencies of M184V/I, K103N and V106A were 28.2%, 19.2%, and 22.1%, respectively.
Result: As for the most prevalent mutations associated with NNRTI, the frequencies of K103N and V106A were approximately 20% (19.2% and 22.1%, respectively).
Table: V106A
Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy.
Result: Of the remaining nine participants failing a LPV/r regimen, M184V was observed in one subject and K103N, V106A and Y188C in another female subject (with no previous sdNVP exposure reported).
Result: The Y181C and V106A mutations only occurred in participants accessing a failing NVP-containing regimen (41% and 9%, respectively).
Result: The most frequent mutation was K103N (n=3; 23%) followed by V106A/M (n=2; 15%).
Discussion: NVP uniquely selected for Y181C (41%) and the V106A (9%) and both the K103N and V106M mutations were more frequent i
HIV-1 subtype D infections among Caucasians from Northwestern Poland--phylogenetic and clinical analysis.
Result: Additional mutations in the HIV-1 genome were detected in three women: One woman each harbored the V106A (together with K103N, Y181C and M184V), the K65R (together with T215F) and the G190A (together with Y181C) mutation, respectively (Table 3, nos.
Result: We also checked population sequences for additional AZT/3TC/NVP-selected resistance mutations like M41L, D67N, K70R, L210W, T215Y/F and K219QE for AZT, K65R for 3TC and
Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP.
Introduction: There are four types of NNRTIs-resistant mutations: (1) Primary mutation: these mutations emerge earliest during therapy and cause high-level resistance to one or more NNRTIs, including K103N/S, Y181C/I/V, V106A/M, Y188L/C/H, and G190A/S/E.
HIV type 1 virological response and prevalence of HIV type 1 drug resistance among patients receiving antiretroviral therapy, Shandong, China.
PMID: 22563717
2012
AIDS research and human retroviruses
Abstract: The most common mutations were thymidine-analog mutations (22.5%) and M184V (10%) to nucleoside reverse transcriptase inhibitors (NRTIs), and V106I/A /M (17.5%), Y181C (15%), and H221Y (12.5%) to non-NRTIs (NNRTIs); 13 patients had mutations to both NRTIs and NNRTIs.
Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro.
Discussion: Y181C, K103N, G190A, Discussion: In previous in vitro studies, both Y181C and V106A have been reported as initial mutations resistant to NVP in both subtype B and C viruses, but V106A was not an initial mutation selected by NVP treatment in this study.
Discussion: Thus far, about 32 NVP-resistance associated mutations in 17 positions, including 15 major NVP-resistant mutations at 5 positions (K103NST, V106AM, Y181CIV, Y188LHC, G190ASEQ), have been summarized in HIV drug resistance database of Stanford University.
HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis.
HIV mutation literature information.
PMID: 
2013
PloS one
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