Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy.
Abstract: The mutant viruses showed the following amino acid substitutions in their reverse transcriptase (RT): Leu-100-->Ile for HIV-1/BHAP; Lys-103-->Asn for HIV-1/TIBO; Val-106-->Ala for HIV-1/Nev; and Glu-138-->Lys for HIV-1/TSAO-m3T.
3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors.
PMID: 1282792
1992
Antimicrobial agents and chemotherapy
Abstract: BI-RG-587 induced a different mutation (V106-->A) in AZT resistance backgrounds.
Abstract: However, the V106-->A substitution did not cause suppression of preexisting AZT resistance.
HIV mutation literature information.
PMID: 
1993
Journal of virology
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