Abstract: Of the 42 aa substitutions currently associated with
INI resistance, 21 occurred as natural polymorphisms:
V72I,
L74I,
T97A,
T112I,
A128T,
E138K,
Q148H,
V151I,
S153Y/A,
M154I,
N155H,
K156N,
E157Q,
G163R,
V165I,
V201I,
I203M,
T206S,
S230N and
R263K.