literature

HIV mutation literature information.

No difference in HIV-1 integrase inhibitor resistance between CSF and blood compartments.

PMID: 33693680 2021 The Journal of antimicrobial chemotherapy

Abstract: The HIV-1 integrase sequences from CSF presented resistance mutations for 9/27 (33.3%) and 8/32 (25.0%) for ARV-naive (L74I, n = 3; L74I/M, n = 1; T97A, n = 1; E157Q, n = 4) and ARV-treated (L74I, n = 6; L74M, n = 1; T97A, n = 1; N155H, n = 1) patients, respectively.

Short Communication: Integrase Strand Transfer Inhibitors Drug Resistance Mutations in Puerto Rico HIV-Positive Individuals.

PMID: 33800269 2021 International journal of environmental research and public health

Abstract: We identified the Q148HKR, G140S, Y143R, N155H, S147G, and E138EA major drug resistance mutations and the D232DN, T97TA, E157Q, G163GART accessory mutations.

Result: Meanwhile, the T97TA (38%) integrase mutation, when combined with any other major mutation, has been reported to have a synergistic effect, which can reduce susceptibility to these drugs.

Result: We also identified the resistance-accessory mutations D232DN, T97TA

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana.

PMID: 33807382 2021 Viruses

Discussion: It was recently shown that it is only upon the development of the T97A mutation that variants harboring Q148H and G140S Integrase mutations started to have increased VLs.

Discussion: This is in contrast to Y143C/R/H (n = 12), N155H (n = 9) and T97A(n = 13) from a similar study in the region where HIV-1C also predominates.

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice.

PMID: 34327247 2021 Open forum infectious diseases

Result: Because genotypic resistance tests for INIs were not available for a substantial number of patients (648 of 669, 96.8%), no association between INI-RAMs and VF could be assessed; a minor mutation was detected (T97A) in only 3 patients in a previous genotypic test, including 1 patient who subsequently experienced VF.

Discussion: As expected, no major INIs RAMs were detected, and only a minor mutation, T97A, was detected in 3 patients, one of whom subsequently experienced VF.

Discussion: Because no impact on failure of first-generation INI has been reported, a causal relationship of T97A alone on VF is debatable.

Characterizing HIV-1 Genetic Subtypes and Drug Resistance Mutations among Children, Adolescents and Pregnant Women in Sierra Leone.

PMID: 34573296 2021 Genes

Result: No PIs RAMs were observed, whereas three accessory INSTI-selected mutations T97A (n = 1), E157Q (n = 2), and G163R (n = 1), which have minimal effect on INSTI susceptibility, were observed in four pregnant women.

Result: Polymorphic accessory INSTI-selected mutations, which have minimal effect on INSTI susceptibility were observed in 8 children/adolescents, as follows: T97A (n = 2), E157Q (n = 5), and S230SR (n = 1).

Discussion: Despite this, we found several polymorphic accessory INSTI-selected mutations (e.g.,

PMID: 34453542 2021 The Journal of antimicrobial chemotherapy

Abstract: RESULTS: HIV-1 IN-recombinant viruses harbouring single primary mutations (N155H or Y143R/S) or in combination with secondary INSTI mutations (T97A, M50I, L74IM, E157Q, G163R or V151I) were susceptible to both bictegravir and cabotegravir.

Variability in HIV-1 Integrase Gene and 3'-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy.

PMID: 32106437 2020 International journal of molecular sciences

Result: The INSTIs accessory RAMs E157Q and T97A were present, respectively, in 6 (all CRF02_AG) and 2 (1 CRF02_AG and 1 CRF09_cpx) samples (Table 2).

Result: The INSTIs accessory RAMs identified in both AG and AG database samples included T97A, E157Q, M50I, L74M, L74I, and S230N (in 3.5% to 60% of AG and in 1.4% to 86.5% of non-AG database samples).

Result: The INSTIs accessory RAMs identified in both cohort and database samples included T97A, E157Q, M50I, L74M<

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

PMID: 32105319 2020 The Journal of antimicrobial chemotherapy

Result: Four had T97A [this was the consensus in three of them and a minority variant in one (who also had L74I)], another participant had an E138K minority variant and another had a G140A minority variant.

Characterization of HIV-1 Integrase Gene and Resistance Associated Mutations Prior to Roll out of Integrase Inhibitors by Kenyan National HIV-Treatment Program in Kenya.

PMID: 32116431 2020 Ethiopian journal of health sciences

Abstract: However, polymorphic accessory mutations associated with reduced susceptibility of integrase inhibitors were observed in low frequency; M50I (12.2%), T97A (3.7%), S153YG, E92G (1.6%), G140S/A/C (1.1%) and E157Q (0.5%).

Result: These mutations were M50I (12.2%), T97A (3.7%), S153YG, E92G (1.6%), G140S/A/C (1.1%) and E157Q (0.5%).

Table: T97A

Circulating HIV-1 Integrase Genotypes in Tanzania: Implication on the Introduction of Integrase Inhibitors-Based Antiretroviral Therapy Regimen.

PMID: 32126792 2020 AIDS research and human retroviruses

Abstract: No major INSTI resistance mutations were found; however, accessory resistance mutations at positions T97A, E157Q, G163E/K, and 128A/T were detected in 5% of subjects.

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