[The efficacy of antiviral therapy and drug resistance analysis among HIV/AIDS patients with heroin addiction in Guangxi Zhuang Autonomous Region].
PMID: 25573121
2014
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Abstract: Among the patients who received antiviral treatment, the mutation frequency of M184V/I, T215Y/F, L210W and T69N/S in heroin abuser group were significantly higher than that in never using drug group (14.9% (11/74) vs 4.4% (3/68), 12.2% (9/74) vs 1.5% (1/68), 12.2% (9/74) vs 1.5% (1/68) and 10.8% (8/74) vs 1.5% (1/68) respectively) (P < 0.05).
Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya.
PMID: 25140907
2014
Journal of acquired immune deficiency syndromes (1999)
5Result: Consensus sequencing confirmed baseline mutations in 6 of the 7 participants identified by OLA, and detected baseline mutations at sites associated with ""potential low-level resistance"" to didanosine and abacavir or ""low-level resistance"" to zidovudine and stavudine in 4 additional participants at codons not evaluated by OLA (T215T/I, n=1; T69S, n=1; T69T/N, n=2) (hivdb.stanford.edu)."
The prevalence of transmitted HIV drug resistance among MSM in Anhui province, China.
Result: T69A/N/S, V179E and P236L were polymorphism mutations against RTIs.
Discussion: For example, L10V, V11I/V, L33F, T69A/N/S, and
Discussion: Other commonly observed mutations were T69A/N/S, V179E, L10I/L/V, V11I/V, L33F, and A71A/T/V; none of these mutations is known to confer drug resistance to NRTIs, NNRTIs, or PIs.
Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.
Result: The frequencies of some mutations, including A71TV, T69S, and V179D were relatively high between the therapy-naive and the ART-failure individuals but the impact on susceptibility to antiviral drugs was low; therefore, these mutations were not described in detail in this study.
Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients.
PMID: 23467175
2013
The Journal of antimicrobial chemotherapy
Abstract: We observed eight therapy-naive patients infected with HIV harbouring four mutations at nucleoside reverse transcriptase inhibitor (NRTI) resistance-related positions: M41L, T69S, L210E and T215S.
Transmitted HIV drug resistance in treatment-naive Romanian patients.
Result: Several atypical substitutions at key positions known to be linked with drug resistance were detected also within the RT gene: for NRTI-T69S (1/61 patients), T69N (2/61 patients) and for NNRTI-E138A/ G (5/61 patients), H221Y (1/61 patients).
Major groove binding track residues of the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase enhance cDNA synthesis at high temperatures.
Abstract: Two of the most thermostable RTs (i.e., mutants T69SSG/K358R/A359G/S360A and K358R/A359G/S360A/E478Q) showed moderately increased fidelity in forward mutation assays.
Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene.
Abstract: After confirmation of treatment failure, resistance to antiretroviral drugs testing was performed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69S mutation.
Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.
HIV mutation literature information.
PMID: 
2014
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
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