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 HIV mutation literature information.


  4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro.
 PMID: 11302824       2001       Antimicrobial agents and chemotherapy
Abstract: These 4'-E analogs also suppressed replication of various drug-resistant HIV-1 clones, including HIV-1(M41L/T215Y), HIV-1(K65R), HIV-1(L74V), HIV-1(M41L/T69S-S-G/T215Y), and HIV-1(A62V/V75I/F77L/F116Y/Q151M).


  Analysis of HIV-1 mutation patterns in patients failing antiretroviral therapy.
 PMID: 11170234       2001       Journal of clinical laboratory analysis
Abstract: We have found no mutations encoding for multiple dideoxynucleoside resistance (Q151M or T69SS).


  Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
 PMID: 10898683       2000       Antimicrobial agents and chemotherapy
Abstract: Study samples (n = 363) collected between 1991 and 1997 from patients exposed to two or more nucleoside analogue reverse transcriptase inhibitors (NRTIs) and 274 control samples from patients exposed to no or one NRTI were screened for two marker mutations of multinucleoside resistance (the Q151M mutation and a mutation with a 2-amino-acid insertion at codon 69, T69S-XX).
Abstract: and T69S-XX was identified in two of the study samples (0.5%; both of them T69S-SS), but both patterns were absent among control samples.


  The reverse transcriptase codon 69 insertion is observed in nucleoside reverse transcriptase inhibitor-experienced HIV-1-infected individuals, including those without prior or concurrent zidovudine therapy.
 PMID: 10551735       1999       Journal of human virology
Abstract: The T69S mutation and the 6-bp insertion following RT codon 69 were the only RT mutations observed in the 2 subjects with a history of D4T-based therapy.


  Different outcome in the first two patients with an HIV-1 multinucleoside drug-resistant T69SSS insertion in Spain.
 PMID: 10682159       1999       Antiviral therapy
Abstract: Herein, we report the first two patients in Spain carrying viral populations with the 69-SS insert coupled to the T69S mutation.



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