literature

HIV mutation literature information.

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.

PMID: 29074854 2017 Scientific reports

Method: Analysis of pol sequences showed that 11 of these 32 subjects (34.3%) were infected with viruses harboring major DRMs, includin

Method: Subject NA2CMR151 harbored viruses with both the Gag cleavage site mutations S373Q, T375G, I376V, G381S; the major NRTIs resistance mutations T69N, K70R, M184V, K219Q; the major NNRTIs resistance mutation Y181C, and the secondary NNRTIs resistance mutations A98G.

Table: T69N

Community Based Antiretroviral Treatment in Rural Zimbabwe.

PMID: 28899102 2017 AIDS research and human retroviruses

Abstract: Seven participants had sequence data available, and five had drug resistance mutations, K65R, T69N, K101E, K103N, Y181C/I, M184V, and G190A.

HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.

PMID: 28750025 2017 PloS one

Table: T69N

HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China.

PMID: 28114955 2017 AIDS research and therapy

Result: One participant infected through heterosexual contact harbored dual mutations in NRTIs (T69N, M184V, and T215Y) and NNRTIs (K103N and M230L), and presented with high-level resistance to lamivudine (3TC) and emtricitabine (FTC) with M184V, intermediate-level resistance to zidovudine (AZT) and stavudine (D4T) with T215Y, and intermediate or high-level resistance to all NNRTIs with K103N and M230L.

Table: T69N

Use of Proviral DNA to Investigate Virus Resistance Mutations in HIV-infected Zimbabweans.

PMID: 28553415 2017 The open microbiology journal

Abstract: Six-percent (n=6) had at least one HIVDR mutation, comprising NRTI-associated mutations, (M184V, T69D, T69N and V75I); NNRTI-associated mutations (G190A, K103N, V106M, Y181C) and thymidine analogue associated mutations (D67N, K70R, K219Q, L210W, M41L, T215Y).

Result: The mutations observed were; NRTI mutations T69D, T69N

Evolutionary Dynamics and Complicated Genetic Transmission Network Patterns of HIV-1 CRF01_AE among MSM in Shanghai, China.

PMID: 27698457 2016 Scientific reports

Result: Only 2 networks for M46L, 6 networks for T69N, and 1 network for P225H were found in lineage 1C and 1B, lineage 1D, 1B, 1 A, small lineage, lineage1D, and lineage 1D, respectively.

Result: Only one individual harbored three mutations including M46I, A62V and T69N.

Result: Overall, four main network-related drug resistant mutations (some were non-tansmitted drug resistance mutations) were discovered at V179D/E (n = 53), M46L (n = 15), T69N (n = 8), and P225H (n = 2).

Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.

PMID: 26483513 2016 The Journal of antimicrobial chemotherapy

Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.

Genetic Characteristics of CRF01_AE Among Newly Diagnosed HIV-1-Infected 16- to 25-Year Olds in 3 Geographic Regions of Guangxi, China.

PMID: 26020400 2015 Medicine

Result: Two TDR mutations, M46I (2) and I50V (1) were found in the protease region, and the other eight TDR mutations, K65E(1), D67N(1), T69N(1), K103N(1), Y181C(2), G190E(1), L210W(1), and P225H(1) were from the reverse transcriptase fragment.

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: T69N

Viral Genetic Diversity and Polymorphisms in a Cohort of HIV-1-Infected Patients Eligible for Initiation of Antiretroviral Therapy in Abuja, Nigeria.

PMID: 25582324 2015 AIDS research and human retroviruses

Result: Among all the mutations detected, T74S (54.5%) in PR and E138A (17%), V179I

Result: We also detected NRTI selected mutations M41L, E44D, T69ANS, V75M, and V118I, and NNRTI mutations V90I, A98G, K101EQ, K103NR, V106I, V108I, E138A, V179EI, and G190A (Table 3).

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