literature

HIV mutation literature information.

HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.

PMID: 21633285 2011 AIDS (London, England)

Result: Other NRTI-associated mutations detected included T69A/N/S (n=21), V75L, V118I and T215A/I.

High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lome, Togo.

PMID: 21663632 2011 Journal of the International AIDS Society

Table: T69N

Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

PMID: 21297946 2011 PloS one

Introduction: The authors reported a faster rate of reversion for primary resistance mutations (K70R, M184I/V, T215Y/F in RT, and D30N, M46I/L, V82A, L90M in PR) compared to secondary mutations (M41L, D67N, T69D/N, L210W, K219Q/E in RT and L10I/V, L63P, A71V/T, V77I in PR)

Correlation between resistance profile and immunosuppression in heavily treated HIV-1 infected Romanian patients.

PMID: 22180722 2011 Romanian biotechnological letters

Result: Thymidine analog mutations, TAMs, selected by zidovudine (AZT) and stavudine (D4T) were usually accompanying this mutation; TAM-2 pathway (mutations D67N, K70R, T215F) was most commonly encountered in immunossupressed patients (28.6%), as well as other substitutions that by themselves, or while accompanying other mutations, confer NRTI resistance: K219E/K/Q (38.1%) and T69N (19%).

Drug resistance mutations in patients infected with HIV-2 living in Spain.

PMID: 21558334 2011 The Journal of antimicrobial chemotherapy

Abstract: No major mutations associated with drug resistance in HIV-1 were recognized in 29 PR, 20 RT and 5 INT sequences from antiretroviral-naive HIV-2 individuals, although natural polymorphisms with potential effects on susceptibility to PR inhibitors were recognized at 10 positions (L10V/I, V32I, M36I, M46I, I47V, Q58E, A71V/I, G73A, V82I and L89I/V) and for nucleoside reverse transcriptase inhibitors at three positions (T69N, V75I

The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains.

PMID: 21569325 2011 Retrovirology

Result: In addition, the analysis showed that drug resistance mutation T69N was genetically linked to Q151M MDR mutations and was acquired prior to Q151M.

Efficacy and safety of 1-month postpartum zidovudine-didanosine to prevent HIV-resistance mutations after intrapartum single-dose nevirapine.

PMID: 20158398 2010 Clinical infectious diseases

Result: One PHPT-4 subject and two PHPT-2 controls already had NRTI resistance mutations detected at baseline (two T69N, one M41L).

Table: T69N

Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.

PMID: 20649426 2010 The Journal of infectious diseases

Result: None of the samples had mutations at the following positions in HIV-1 reverse transcriptase that have been associated with acyclovir selection in vitro: V75I, T69N, W71X, R72X, Q151M, and M184V.

Genetic characterization of HIV-1 strains in Togo reveals a high genetic complexity and genotypic drug-resistance mutations in ARV naive patients.

PMID: 19460333 2009 Infection, genetics and evolution

Abstract: A total of 8 patients harbored strains with mutations associated to drug resistance: L90M (n=1), K103N (n=1), T69N (n=1), T215S (n=1), M41L (n=4).

The K65R mutation in HIV-1 reverse transcriptase: genetic barriers, resistance profile and clinical implications.

PMID: 20190870 2009 HIV therapy

Introduction: The development of K65R and Q151M may be facilitated for HIV-2 variants originating from West Africa (Senegal and Portugal), harboring NNRTI mutations (K101A, V106I, V179I, Y181I, Y188L and G190A) and TAMs/NAMs (T69N, V75I, V118I, L210N, T215S and K219E) as natural polymorphisms.

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