literature

HIV mutation literature information.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Result: Mutations M41L (above) and L74I/V (below) were outside the CI for Portugal but not for DE, and T69N (above) and K65R (below) were outside the CI for DE but not for Portugal.

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: T69N

Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.

PMID: 26107265 2015 PloS one

Table: T69N

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Result: T69A and T69N accounted for 0.9% and 1.9%, respectively.

Result: The drug resistance mutation loci included A71V, D67H, T69N, K70R, T215F, K219E, A98G, V179D, and Y181C, with HNHIV97 and HNHIV113 clustered together.

Table: T69A/N

[Resistance evolutionary pathway analysis of HIV-1 CRF_07BC reverse transcriptase].

PMID: 24969455 2014 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Abstract: While for B subtype, the major resistance mutations include M184V, K103N,Y181C, T69N,G190A, K238T,Y188H and P225H.

Oligonucleotide ligation assay detects HIV drug resistance associated with virologic failure among antiretroviral-naive adults in Kenya.

PMID: 25140907 2014 Journal of acquired immune deficiency syndromes (1999)

5Result: Consensus sequencing confirmed baseline mutations in 6 of the 7 participants identified by OLA, and detected baseline mutations at sites associated with ""potential low-level resistance"" to didanosine and abacavir or ""low-level resistance"" to zidovudine and stavudine in 4 additional participants at codons not evaluated by OLA (T215T/I, n=1; T69S, n=1; T69T/N, n=2) (hivdb.stanford.edu)."

Result: The remaining 6 individuals had mutations at non-OLA codons, all at frequencies <2%, except for 3 individuals: one with L210W detected at a frequency of 5.9%, and two with T69N detected; one at a frequency of 22.5% and the second at 25.0% (Figure 3).

HIV-1 pol diversity among female bar and hotel workers in Northern Tanzania.

PMID: 25003939 2014 PloS one

Introduction: In HIV-1 CRF01_AE infection, the RT mutations T69N and V75M were seen more frequently than in HIV-1 subtype B.

The prevalence of transmitted HIV drug resistance among MSM in Anhui province, China.

PMID: 25035709 2014 AIDS research and therapy

Result: T69A/N/S, V179E and P

Discussion: For example, L10V, V11I/V, L33F, T69A/N/S, and P236L were present only in individuals with CRF01_AE strains.

Discussion: Other commonly observed mutations were T69A/N/S, V179E, L10I/L/V, V11I/V, L33F, and A71A/T/V; none of these mutations is known to confer drug resistance to NRTIs, NNRTIs, or PIs.

[The efficacy of antiviral therapy and drug resistance analysis among HIV/AIDS patients with heroin addiction in Guangxi Zhuang Autonomous Region].

PMID: 25573121 2014 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Abstract: Among the patients who received antiviral treatment, the mutation frequency of M184V/I, T215Y/F, L210W and T69N/S in heroin abuser group were significantly higher than that in never using drug group (14.9% (11/74) vs 4.4% (3/68), 12.2% (9/74) vs 1.5% (1/68), 12.2% (9/74) vs 1.5% (1/68) and 10.8% (8/74) vs 1.5% (1/68) respectively) (P < 0.05).

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.

PMID: 25575025 2014 Retrovirology

Table: T69N

Browser Board

Co-occurred Entities

Filtrator