Abstract: SDRMs were identified in 14/219 (6.4%) subjects; 8/14 were resistant to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs; T69D, L74V, V75M, M184V/I and K219R), 5/14 to non-nucleoside reverse transcriptase inhibitors (NNRTIs; K103N, V106M, Y181C, Y188C and G190A), 1/14 to both NRTIs and NNRTIs (D67N and Y181C) and none to PMID: 22047156
2011
Molecular diagnosis & therapy
Abstract: Mutations E44A, T69D, and V118I influenced the pattern of resistance of TAMs.
Prevalence of antiretroviral drug resistance mutations and HIV-I subtypes among newly-diagnosed drug-naive persons visiting a voluntary testing and counselling centre in northeastern South Africa.
PMID: 21957668
2011
Journal of health, population, and nutrition
Abstract: Four (7.4%) of these were nucleoside RT inhibitor mutations (D67G, D67E, T69D, and T215Y), and one (1.9%) was a PR inhibitor mutation (M46I).
Result: These included four NRTI mutations (D67E, D67G, T69D, and T215Y) harboured by sequences 08MB38ZA, 08MB26ZA, 08MB27ZA, and 08MB29ZA respectively, and one PI resistance mutation (M46I) observed in sequence 08MB62ZA.
Discussion: In the same vein, T69D causes low-level resistance to didanosine, with a potential
High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lome, Togo.
PMID: 21663632
2011
Journal of the International AIDS Society
Table: T69D
Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.
Abstract: Between baseline and 2 months of STI, T215F had the fastest rate of reversion (41%) and the reversion of E44D and T69D was associated with the largest changes in RC.
Introduction: The authors reported a faster rate of reversion for primary resistance mutations (K70R, M184I/V, T215Y/F in RT, and D30N, M46I/L, V82A, L90M in PR) compared to secondary mutations (M41L, D67N, T69D/N, L210W,
Development of a didanosine genotypic resistance interpretation system based on large derivation and validation datasets.
Abstract: RESULTS: The ddI resistance mutations and their resistance scores based on the derivation set were as follows: M41L (score of 14), T69D (24), D123S (40), T139M (54), I180V (53), M184V (-12), V189I (55), Q207K (37), L210W (25), and T215Y (eight).
Antiretroviral drug resistance surveillance among drug-naive HIV-1-infected individuals in Gauteng Province, South Africa in 2002 and 2004.
Abstract: Of these, one had T69D and one had the K70R resistance mutation, to give a total of 2/48 (4.2%) participants with evidence of resistance mutations by genotyping.
Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients in Greenland.
PMID: 18620490
2008
AIDS research and human retroviruses
Abstract: The most prevalent mutations were T69D/N (15%), K70R (15%), and M184V (10%).
Improved interpretation of genotypic changes in the HIV-1 reverse transcriptase coding region that determine the virological response to didanosine.
PMID: 18008248
2007
The Journal of infectious diseases
Abstract: The best correlation with response was found with the derived score (M41L x 2) + E44D/A/G + T69D/S/N/A + (L210W x 2) + T215Y or revertants + L228H/R - D123E/N/G/S, by use of which viruses were categorized as being susceptible (score < or =0), as having intermediate resistance (1-3), and as being resistant (> or =4) to didanosine.
HIV mutation literature information.
PMID: 
2013
Journal of the International AIDS Society
Browser Board
Co-occurred Entities
Filtrator
ViMRT