literature

HIV mutation literature information.

Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.

PMID: 25926858 2014 AIDS research and therapy

Result: N[t]RTI RAMs were found in 14% of patients (43/313; 36 and seven patients), most commonly V118I (6%; 18/313; 18 and zero patients), T69D/N (3%; 8/313; eight and zero patients) and M184V/I (3%; 8/313; two and six patients).

The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy.

PMID: 25926857 2014 AIDS research and therapy

Result: It showed that M41L, D67N, T69D, K70R, and K219R were the most common NRTI mutations that associated with the three NNRTI mutations, K103N, Y181C and G190A.

Table: T69D

Virological failure and HIV-1 drug resistance mutations among naive and antiretroviral pre-treated patients entering the ESTHER program of Calmette Hospital in Cambodia.

PMID: 25166019 2014 PloS one

Result: V75T/M and T69D/N mutations, associated with decreased susceptibilities to d4T and ddI, were detected in 4/22 (18.1%) and 6/22 (27.2%) patients.

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Table: T69D

Limited evolution but increasing trends of primary non-nucleoside reverse transcriptase inhibitor resistance mutations in therapy-naive HIV-1-infected individuals in India.

PMID: 24699043 2014 Antiviral therapy

Abstract: Common mutations included T69D and D67N (NRTI mutations), and L100I, K101E, K103N and Y181C (NNRTI mutations).

Transmitted HIV drug resistance in treatment-naive Romanian patients.

PMID: 23592112 2013 Journal of medical virology

Result: M184V, the 3TC-selected mutation was identified in three HIV resistant strains, alone in two cases and together with all the above mentioned type II TAMs, as well as other NRTI conferring resistance mutations (T69D and L74I) in one case.

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

PMID: 23840622 2013 PloS one

Result: (ii) K65N, which occurred in one patient receiving TDF; (iii) T69D, V75M, and V75T, which occurred in 1.3%, 2.5%, and 0.3% respectively; (iv) T215I occurred in 1.4% of patients; and (v) K219R and K219N, occurred in 1.6% and 0.9% respectively.

Persistence of HIV-1 transmitted drug resistance mutations.

PMID: 23904291 2013 The Journal of infectious diseases

Table: T69D

Prevalence and mutation patterns of HIV drug resistance from 2010 to 2011 among ART-failure individuals in the Yunnan Province, China.

PMID: 24009694 2013 PloS one

Table: T69D

Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

PMID: 24093951 2013 Journal of the International AIDS Society

Table: T69D