literature

HIV mutation literature information.

Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.

PMID: 30648124 2019 Open forum infectious diseases

Conclusion: At that time, resistance testing showed NRTI (M184V, T69D, T215S, D67N, K219Q), NNRTI (Y181C, Y188L, H221Y) and PI (L10I, D30N, K20T, L33F, K43T, N88D) resistance, with PI resistance to nelfinavir.

Table: T69D

Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon.

PMID: 31119759 2019 Transfusion

Abstract: This cluster was characterized by NRTI (D67N, T69D, T215S/F/L, K219Q) and NNRTI (K101H, K103 N, G190A) mutations.

HIV-1 transmitted drug resistance in Slovenia and its impact on predicted treatment effectiveness: 2011-2016 update.

PMID: 29698470 2018 PloS one

Result: The first sequence is part of the largest Slovenian cluster (n = 53) and carries the T69D mutation, the second sequence is within a cluster of 20 Slovenian sequences and carries M46I, and the third is in a phylogenetic relationship with two other Slovenian sequences and is carries K103N (Fig 2).

Discussion: (2017) observed significantly less clustering of mutations T69D and M46I detected in the two sequences within large Slovenian clusters, which indicates that these two mutations are less fit to transmit than the wild type.

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.

PMID: 29977795 2018 African journal of laboratory medicine

Result: Other minority mutations including M41L, A62V, D67N, T69D, V75M, T215F and K219E were found in one sample each.

Table: T69D

Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.

PMID: 30442114 2018 BMC infectious diseases

Table: T69D

Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso.

PMID: 30079168 2018 Journal of public health in Africa

Result: Also, other DRM such as K70R (5.56%), K219Q (5.56%), T69D (5.56%), Y115F (5.56%) and K65R (5.56%) were detected with equal rates in mothers and were associated with resistance to (AZT, 3TC, TDF), 3TC, DDI, ABC and 3TC respectively.

Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.

PMID: 29049402 2017 PloS one

Table: T69D

Use of Proviral DNA to Investigate Virus Resistance Mutations in HIV-infected Zimbabweans.

PMID: 28553415 2017 The open microbiology journal

Abstract: Six-percent (n=6) had at least one HIVDR mutation, comprising NRTI-associated mutations, (M184V, T69D, T69N and V75I); NNRTI-associated mutations (G190A, K103N, V106M, Y181C) and thymidine analogue associated mutations (D67N, K70R, K219Q, L210W, M41L, T215Y).

Result: The mutations observed were; NRTI mutations T69D, T69N

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.

PMID: 29074854 2017 Scientific reports

Method: Other major NRTIs resistance mutations detected included the multidrug resistance mutation T69D, the thymidine analogue mutation (TAM) T215F, and the non-TAMs K65R and Y115F (Table 3).

Method: These transmitted DRMs included major resistance mutations to NRTIs such as M184V, T69D, T215F, K65R, and Y115F; and major resistance mutations to non-Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NNRTIs) such as Y181C, K103N,

Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.

PMID: 26483513 2016 The Journal of antimicrobial chemotherapy

Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.

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