Abstract: Less commonly observed primary
IN mutations also showed a range of reduced EVG susceptibilities: 40- to 94-fold for
T66K and
Q148K and 5- to 10-fold for
T66A,
E92G, and
Q148H.
Abstract: Primary
INSTI resistance-associated mutations (RAMs) at six
IN positions have been identified in
HIV-1-infected patients failing EVG-containing regimens in clinical studies:
T66I/A/K,
E92Q/G,
T97A,
S147G,
Q148R/H/K, and
N155H.