Application of a colorimetric chain-termination assay for characterization of reverse transcriptase from 3'-azido-2',3'-deoxythymidine-resistant HIV isolates.
PMID: 12074693
2002
Biotechnology and applied biochemistry
Abstract: The Thr-39-->Ala substitution has previously been recorded in connection with AZT/Foscarnet combination therapy.
Abstract: The four deviating isolates contained either a minimum of four AZT-specific substitutions, including Thr-215-->Tyr (isolates 134 and 143), or some of the known specific substitutions combined with Thr-39-->Ala (isolates 80 and 157).
Coresistance to zidovudine and foscarnet is associated with multiple mutations in the human immunodeficiency virus type 1 reverse transcriptase.
PMID: 9797252
1998
Antimicrobial agents and chemotherapy
Abstract: Six of these mutations were nonpolymorphic (T39A, V108I, K166R, K219R, K223Q, and L228R).
HIV mutation literature information.
PMID: 
2002
Biotechnology and applied biochemistry
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