Discussion: For example, T39A and K43E had three (M41L, K43E, and M184V) and seven (D67N, L74V, K101E, L210W, M184V, T215Y, and E224D) target drug resistance mutations, respectively.
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Result: Sequence comparisons of HIV-1 positive naive and HAART treated patients revealed a correlation between K20R and 3TC resistance and an association with TAMs, while T39A appears to be associated with previous AZT and d4T treatment and with the development of TAMs.
Transmitted HIV drug resistance in treatment-naive Romanian patients.
Result: The analysis of the RT gene also revealed many accessory mutations presented in all studied sequences, encountered most frequently at positions V35T, T39A, V60I, I135L, A272P, I293V.
Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.
Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.
Result: The frequency of accessory mutations such as T39A, H208Y and L228H was also significantly higher in the treated population compared with the naive group.
Table: T39A
Discussion: Among them, T39A, V179I, H208Y, K223E, L228H/R, R284K and V292I have been previously identified as secondary mutations associated with the accumulation of TAMs and with resistance to nucleoside analogues.
Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.
Introduction: These mutations include the K20R, V35M, T39A, E40F, K43E/Q/N, A98G, K122E, G196E, E203K/D, H208Y, D218E, H221Y, K223E/Q and L228H/R changes.
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
Abstract: A correlation was found between K20R and lamivudine resistance (P = 0.006) while T39A (P = 0.005), K43EQN (<0.001), E203KD (P = 0.010), and H208Y (P = < 0.001) seemed to be associated with a previous use of zidovudine and stavudine and with the development of thymidine analog resistance.
Abstract: The mutations involving 10 of these positions were associated with a reduced susceptibility to antiretroviral drugs; K20R, T39A, K43EQN, E203KD, H208Y, and D218E were correlated with NRTI resistance while mutations PMID: 16809324
2006
Journal of virology
Abstract: In particular, T39A, K43E/Q, K122E, E203K, and H208Y clustered with the nucleoside analogue mutation 1 cluster (NAM1; M41L+L210W+T215Y).
HIV mutation literature information.
PMID: 
2017
PloS one
Browser Board
Co-occurred Entities
Filtrator
ViMRT