literature

HIV mutation literature information.

Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana.

PMID: 24119088 2013 BMC infectious diseases

Result: Thymidine-associated mutations (TAMs) were rare with only one patient (1 of 8, 12.5%) harboring T215Y mutation in combination with M184V.

Table: T215Y

Incidence and risk factors for first line anti retroviral treatment failure among Ugandan children attending an urban HIV clinic.

PMID: 24215971 2013 AIDS research and therapy

Result: Other common NRTI RAMs were the K70R (n = 22; 20%), T215Y (n = 36; 24%), M41L (n = 23; 21%), D67N (n = 15; 14%), K219Q/E (n = 14; 13%) and the L210W making 9% of the TAMs.

Highly-sensitive allele-specific PCR testing identifies a greater prevalence of transmitted HIV drug resistance in Japan.

PMID: 24358257 2013 PloS one

Abstract: To detect minority populations with drug resistance, we used AS-PCR with mutation-specific primers designed for seven reverse transcriptase inhibitor resistance mutations, M41L, K65R, K70R, K103N, Y181C, M184V, and T215F/Y, and for three protease inhibitor resistance mutations, M46I/L and L90M.

Method: Briefly, mutation-specific primers were designed for seven reverse transcriptase inhibitor resistance mutations, M41L, K65R, K70R,

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.

PMID: 21908397 2012 Nucleic acids research

Discussion: HIV-1 RTs containing the M41L, D67N, K70R, T215Y/F, K219E/Q mutations show enhanced removal of AZT.

Drug resistance mutations in HIV pol sequences from Argentinean patients under antiretroviral treatment: subtype, gender, and age issues.

PMID: 21936717 2012 AIDS research and human retroviruses

Abstract: The most common DRMs were L10I, I54V, L90M, V82A, A71V, L10V, M46I, M184V, M41L, T215Y, D67N, L210W, K70R, N348I, V118I, K103N, Y181C, G190A, K101E, V108I, L100I, V90I, K101Q, and

PMID: 22138483 2012 Antiviral research

Abstract: E17A was associated with thymidine analog mutations (TAMs) in reverse transcriptase M41L, L210W and T215Y and with the use of didanosine in the patients' treatment histories.

HIV-1 subtype D infections among Caucasians from Northwestern Poland--phylogenetic and clinical analysis.

PMID: 22359615 2012 PloS one

Table: T215Y

Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

PMID: 22363673 2012 PloS one

Abstract: Mutations significantly associated with AZT monotherapy included K70R (p = 0.003) and T215Y (p = 0.013) in the polymerase domain of HIV-1 RT, and A360V (p = 0.041) in the connection domain of HIV-1 RT.

Method: The A360V mutation was also introduced by site-directed mutagenesis (QuickChange II Site-Directed Mutagenesis Kit; Agilent, La Jolla, CA) into the backbone of wildtype HIV-1

Result: Although each of the known TAMs was identified in one or more on-treatment samples, only the K70R and T215Y mutations were significantly associated with AZT monotherapy.

Emergence of minor drug-resistant HIV-1 variants after triple antiretroviral prophylaxis for prevention of vertical HIV-1 transmission.

PMID: 22384138 2012 PloS one

Introduction: For this purpose, we developed, evaluated and applied highly sensitive allele-specific PCR (ASPCR) assays enabling the detection and quantification of three key mutations for AZT resistance (K70R, T215Y and T215F), the two most common NVP-associated resistance mutations (K103N and Y181C) and the most frequent 3TC-selected mutation M184V in the pol open reading frame with a detection limit of <1%.

Result: Genotypic mutations associated with decreased susceptibility to AZT were detected in 11/50 (22%) women (7/50 (14%) containing K70R alone and 4/50 (8%) with T215Y/F mutation) whereas 9/50 (18%) women harbored NVP-resistant virus (K

Low prevalence of transmitted drug resistance in patients newly diagnosed with HIV-1 infection in Sweden 2003-2010.

PMID: 22448246 2012 PloS one

Table: T215Y

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