literature

HIV mutation literature information.

[Analysis of HIV genotypic drug resistance among pediatric HIV/AIDS cases with virological failure after free antiretroviral therapy in Yunnan province].

PMID: 24854905 2014 Zhonghua yi xue za zhi

Abstract: The prevalent mutations associated with drug resistance were M184V/I, K103N, T215F/Y, G190A, Y181C and K101E at the frequencies of 52.1% (38/73), 30.1% (22/73), 21.9% (16/73), 20.5% (15/73), 15.1% (11/73) and 12.3% (9/73) respectively.

HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.

PMID: 24740633 2014 The Journal of infectious diseases

Result: The participant with acute infection who was randomized to placebo had multiclass resistance mutations M184V, T215Y, K103N, and P225H.

Table: T215Y

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Result: We also found a case of a transitional mutation, T215S, which is detected in isolates that eventually go on to develop the NRTI drug resistance mutations T215Y and T215F.

Table: T215Y

Comparison of ultra-deep versus Sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure.

PMID: 24698843 2014 AIDS (London, England)

Abstract: Y181C and T215Y were the most frequent mutations associated with interpretation differences.

Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.

PMID: 24667336 2014 Antiviral research

Abstract: NRTI susceptibility was not affected by the addition of H208Y in phenotypic assays carried out in MT-4 cells using recombinant HIV-1 containing wild-type (subtype B, BH10), H208Y, M41L/L210W/T215Y or M41L/H208Y/L21

Abstract: However, enzymatic studies carried out with purified RTs revealed that in the presence of M41L/L210W/T215Y, H208Y increases the RT's ability to unblock and extend primers terminated with zidovudine, tenofovir and in a lesser extent, stavudine.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Result: HNHIV113 site mutations included A71T, M41L, M184V, L210W, T215Y, K103N, and Y181C.

Result: HNHIV97 locus mutations included D67N, T69A, K70R,

Table: T215F/Y

HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study.

PMID: 24456757 2014 AIDS research and therapy

Table: T215Y

Drug resistance mutations and genetic diversity in adults treated for HIV type 1 infection in Mauritania.

PMID: 24318486 2014 Journal of medical virology

Abstract: Thymidine Analog Mutations (TAMs) were found in 26.0% (n = 17) of strains and the most common was T215Y (n = 11, 16.9%).

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

PMID: 24174331 2014 Proteins

Result: The enhanced rigidity of the palm subdomain adjacent to the T215Y mutated side chain may enhance ATP binding.

Result: this putative effect may be analogous to the impact of L210W accompanying the T215Y/F mutation to enhance ATP binding.

Treatment-naive individuals are the major source of transmitted HIV-1 drug resistance in men who have sex with men in the Swiss HIV Cohort Study.

PMID: 24145874 2014 Clinical infectious diseases

Abstract: Three clusters showed evidence of reversion of K103N or T215Y/F.

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