literature

HIV mutation literature information.

Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019: A Comparison Between the Populations of Late Presenters and Non-late Presenters.

PMID: 35495657 2022 Frontiers in microbiology

Abstract: The most prevalent TDR drug resistance mutations, in both LP and NLP, were K103N/S, T215rev, T215FY, M184I/V, M41I/L, M46I/L, and L90M.

Deep sequencing of HIV-1 reveals extensive subtype variation and drug resistance after failure of first-line antiretroviral regimens in Nigeria.

PMID: 34741609 2022 The Journal of antimicrobial chemotherapy

Result: Sixteen participants had all of the TAM 1 pathway mutations (M41L, L210W and T215Y), 11 had all of the TAM 2 pathway mutations (D67N, K70R, T215F and K219Q/E) and four had the mutations for both pathways.

Rising rates of recent preexposure prophylaxis exposure among men having sex with men newly diagnosed with HIV: antiviral resistance patterns and treatment outcomes.

PMID: 34873084 2022 AIDS (London, England)

Table: T215Y/F

Brief Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide Efficacy in Participants With Preexisting Primary Integrase Inhibitor Resistance Through 48 Weeks of Phase 3 Clinical Trials.

PMID: 34897227 2022 Journal of acquired immune deficiency syndromes (1999)

Table: T215F/Y

Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania.

PMID: 35107140 2022 The Journal of antimicrobial chemotherapy

Abstract: Common mutations in RT were M184V (75%), T215Y (41.1%), K103N (39.3%), M41L (32.1%), D67DN (30.3%), G190A (28.6%) and A98G (26.8%).

Table: T215Y

Discussion: The most plausible explanations for the occurrence of T215Y, D67N, M41L, K219K/Q and K70R TAMs among patients with tenofovir disoproxil fumarate-based ART regimen failure are that these TAMs were transmitted drug resistance RAMs (TDR-RAMs) or were selected by exposure to undisclosed thymidine analogue-based regimens.

Determination of reverse transcriptase inhibitor resistance mutations in HIV-1 infected children in Cote d'Ivoire.

PMID: 33170745 2021 Genome

Abstract: Frequently encountered resistance mutations were for NRTIs: M184V (88%), TAMs (67%), T215F/I/V/Y (33%), and L74I/V (24%); for NNRTIs: K103N/S (74%), P225H (26%), and G190A/E/Q (24%).

High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.

PMID: 34025122 2021 Infectious diseases

Result: For NRTIs, these were M184VI (55.6%), T215SNY (22.2%), and K65R (18.5%).

Virologic outcomes of switching to dolutegravir functional mono- or dual therapy with a non-cytosine nucleoside analog: a retrospective study of treatment-experienced, patients living with HIV.

PMID: 33941212 2021 AIDS research and therapy

8Discussion: However, in the patient on DTG/TDF this ""hypersensitizing"" effect may have been reduced by the presence of baseline M41L and T215Y which in combination are ass

Result: The other patient was switched from TDF/FTC/EVG/c to DTG/ABC/3TC (Table 2, Patient 6) and historical genotypic testing revealed an M184V/I, M41L, T215Y and L74/I which predicted that DTG was the only fully active agent in the study DCR.

Discussion: Among the three patients on functional dual therapy with persistent viremia and documented non-adherence, two were on DTG/ABC and only had baseline M184V/I whereas the other was on DTG/TDF and had baseline M184V/I, M41L and T215Y.

HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil.

PMID: 33788308 2021 Journal of medical virology

Abstract: The most common primary mutations found were M184V (29.5%), K103N (25%), M41L (9.8%), T215Y (8.3%), and G190A (8.3%).

Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Adults With HIV and M184V/I Mutation.

PMID: 33315694 2021 Journal of acquired immune deficiency syndromes (1999)

Table: T215Y/F

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