literature

HIV mutation literature information.

[Analysis of HIV genotypic drug resistance among pediatric HIV/AIDS cases with virological failure after free antiretroviral therapy in Yunnan province].

PMID: 24854905 2014 Zhonghua yi xue za zhi

Abstract: The prevalent mutations associated with drug resistance were M184V/I, K103N, T215F/Y, G190A, Y181C and K101E at the frequencies of 52.1% (38/73), 30.1% (22/73), 21.9% (16/73), 20.5% (15/73), 15.1% (11/73) and 12.3% (9/73) respectively.

HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.

PMID: 24740633 2014 The Journal of infectious diseases

Result: The participant with acute infection who was randomized to placebo had multiclass resistance mutations M184V, T215Y, K103N, and P225H.

Table: T215Y

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Result: We also found a case of a transitional mutation, T215S, which is detected in isolates that eventually go on to develop the NRTI drug resistance mutations T215Y and T215F.

Table: T215Y

Comparison of ultra-deep versus Sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure.

PMID: 24698843 2014 AIDS (London, England)

Abstract: Y181C and T215Y were the most frequent mutations associated with interpretation differences.

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.

PMID: 24667336 2014 Antiviral research

Abstract: NRTI susceptibility was not affected by the addition of H208Y in phenotypic assays carried out in MT-4 cells using recombinant HIV-1 containing wild-type (subtype B, BH10), H208Y, M41L/L210W/T215Y or M41L/H208Y/L21

Abstract: However, enzymatic studies carried out with purified RTs revealed that in the presence of M41L/L210W/T215Y, H208Y increases the RT's ability to unblock and extend primers terminated with zidovudine, tenofovir and in a lesser extent, stavudine.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Result: HNHIV113 site mutations included A71T, M41L, M184V, L210W, T215Y, K103N, and Y181C.

Result: HNHIV97 locus mutations included D67N, T69A, K70R,

Table: T215F/Y

HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study.

PMID: 24456757 2014 AIDS research and therapy

Table: T215Y

Drug resistance mutations and genetic diversity in adults treated for HIV type 1 infection in Mauritania.

PMID: 24318486 2014 Journal of medical virology

Abstract: Thymidine Analog Mutations (TAMs) were found in 26.0% (n = 17) of strains and the most common was T215Y (n = 11, 16.9%).

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

PMID: 24174331 2014 Proteins

Result: The enhanced rigidity of the palm subdomain adjacent to the T215Y mutated side chain may enhance ATP binding.

Result: this putative effect may be analogous to the impact of L210W accompanying the T215Y/F mutation to enhance ATP binding.

Treatment-naive individuals are the major source of transmitted HIV-1 drug resistance in men who have sex with men in the Swiss HIV Cohort Study.

PMID: 24145874 2014 Clinical infectious diseases

Abstract: Three clusters showed evidence of reversion of K103N or T215Y/F.

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