Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Abstract: The most frequent TDR mutations observed were M41L, D67N/G/E, T215F/Y/I/S/C/D/E/V/N, 219Q/E/N/R, K103N/S, and G190A/S/E in reverse transcriptase, and M46I/L and L90M in protease.
Method: To obtain a standard interpretation across tests, HIV-1 transmitted drug resistance was defined according to the World Health Organization (WHO) 2009 surveillance list, with the addition of T215N (a revertant of T215F/Y omitted from the list) and E138K (a nonpolymorphic rilpivirine-associated muta
Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.
PMID: 25680310
2015
Clinical microbiology and infection
Abstract: The most common TC-DRM present in >=50% of them were D67NME, T215FVY, M41L and K103N (retrotranscriptase) and L90M (protease).
Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma.
PMID: 25344810
2015
The Journal of antimicrobial chemotherapy
Abstract: Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P=0.0455) and T215Y (P=0.0455).
Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.
Abstract: The majority of site-directed mutations (M46I/M46L in protease and M41L, M41L + T215Y and K103N in RT) decreased viral replicative capacity; only protease mutation L90M did not hamper viral replication.
Result: The reduction in RC of the M41L, M41L + T215Y and K103N variants was comparable to each other, and to controls HIV
Discussion: Of the investigated site-directed mutant viruses, T215Y is known to evolve to atypical or partial revertant amino acids.
[The efficacy of antiviral therapy and drug resistance analysis among HIV/AIDS patients with heroin addiction in Guangxi Zhuang Autonomous Region].
PMID: 25573121
2014
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Abstract: Among the patients who received antiviral treatment, the mutation frequency of M184V/I, T215Y/F, L210W and T69N/S in heroin abuser group were significantly higher than that in never using drug group (14.9% (11/74) vs 4.4% (3/68), 12.2% (9/74) vs 1.5% (1/68), 12.2% (9/74) vs 1.5% (1/68) and 10.8% (8/74) vs 1.5% (1/68) respectively) (P < 0.05).
HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya.
Abstract: Eight (8) patients had NRTI resistance mutations with NAMS M184V (54.2%) and K65R (8.4%) mutations being the highest followed by TAMs T215Y and K70R (12.5%).
Abstract: However, for NRTI two patients had TAM T215Y.
Result: However four patients had diverse drug mutations combinations of K103N and V108IV (n = 1); Y184V, G190A and T215Y (n = 1); K103N, M184V and T215Y (n = 1); and A98G,
Time to virologic failure for patients taking their first antiretroviral regimen and the subsequent resistance profiles.
PMID: 25397502
2014
Journal of the International AIDS Society
Abstract: Three patients taking PI-based regimens developed NRTI mutations (M184V, M184I, T215Y).
Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses.
PMID: 25397500
2014
Journal of the International AIDS Society
Table: T215Y
Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.
PMID: 25397495
2014
Journal of the International AIDS Society
Abstract: However, thymidine analogue resistance mutations (TAMs) determined two distinct genotypic profiles in the HIV-1 reverse transcriptase: TAM1: M41L, L210W and T215Y, and TAM2: D67N, K70R, K219E/Q, and T215F.
HIV mutation literature information.
PMID: 
2015
Journal of medical virology
Browser Board
Co-occurred Entities
Filtrator
ViMRT