Abstract: Two samples (4%) harboring the mutations M230L and Y181C associated with the TAMs M41L and T215Y, respectively, were found.
Method: In addition, one sample (CgCHU38) from a patient attending the Centre Hospitalier et Universitaire de Brazzaville (CHU-B) and subtyped as G in all 3 regions has the mutations Y181C, M41L and T215Y.
Discussion: Additionally, the sample harboring the mutation T215Y and the TAMs M41L and Y181C sampled at the CHU de Brazzaville (subtype G) was male, but the transmission of these HIV-1 mutations from nevirapine-exposed patients can be suspected.
HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.
Discussion: In our study, we observed that the four TAMs (D67N, K70R, T215Y and K219Q/E) which make up the Type 2 TAM pathway, occurred more frequently and correlated well with the usage of AZT.
Discussion: In this study, there was a noticeable absence among subjects of the L210W and very low occurrence of the M41L DRM, both components of the Type 1 TAMs pathway (M41L, L210W and T215Y).
Discussion: The absence of M41L and L210W was initially reported from a subtype C cohort in Botswana where the most common TAM pathway was
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Method: Primary NRTI-R substitutions assessed were M41L, A62V, K65R, D67N, T69 insertions, K70E/R, L74I/V, V75I, F77L, Y115F, F116Y, Q151M, M184V/I, L210W, T215F/Y, and K219E/N/Q/R in RT.
Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.
PMID: 29026792
2017
Iranian journal of public health
Abstract: The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results of protease revealed G73SC (13.8%) and I47VA (6.9%).
Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.
Result: Among the two TAMs pathways, TAM-2 which features D67N, K70R, T215F, and K219E/Q mutations was more common than the TAM-1 which features M41L, L210W and T215Y.
Table: T215Y
Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.
Result: The most frequently observed reverse transcriptase (RT) drug resistance mutations in NRTI-experienced patients were M184I/V (64.2%), D67N (25.9%), K70R (19.6%), K219Q/E (17.9%) and T215Y/F (13.4%).
Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.
Abstract: Overall, 32% (37/116) patients presented >= one major drug resistant mutation(s), with 29% (34/116) to nucleos(t)ide reverse transcriptase inhibitors (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] Result: Out of the 43 sequences generated, the most prevalent DRMs were: (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] K219E/N/Q and 5% [2/43] A62V, followed by other DRMs observed at low rates.
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively.
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Abstract: Although MR-RT harbored the most significant amino acid exchanges T215Y and Q151M of each pathway, it exclusively used AZTTP discrimination, indicating that the two mechanisms are mutually exclusive and that the Q151M pathway is obviously preferred since it confers resistance to most nucleoside inhibitors.
Abstract: We analyzed a multi-drug resistant (MR) HIV-1 reverse transcriptase (RT), subcloned from a patient-derived subtype CRF02_AG, harboring 45 amino acid exchanges, amongst them four thymidine analog mutations (TAMs) relevant for high-level AZT (azidothymidine) resistance by AZTMP excision (M41L, D67N, T215Y, K219E) as well as
HIV mutation literature information.
PMID: 
2017
BMC research notes
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