literature

HIV mutation literature information.

The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations.

PMID: 30029500 2018 Viruses

Abstract: In particular, A62V was observed in various multi-dideoxynucleoside resistant (MDR) mutation complexes, including the Q151M complex (i.e., A62V, V75I, F77L, F116Y, and Q151M), and the T69SSS insertion complex, which has a serine-serine insertion between amino acid positions 69 and 70 (i.e., M41L, A62V, T69SSS, K70R, and T215Y).

Introduction: In particular, A62V is normally seen in different mutational arrangements, located mostly on the flexible beta3-beta4 loop region of the fingers sub-domain of

Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso.

PMID: 30079168 2018 Journal of public health in Africa

Result: Other mutations such as T215F/Y and D67N/E were also more prevalent in mothers (16.67% and 11.11% respectively) than in infants (5.56% and 5.56% respectively) (Table 3).

Result: The drugs affected by these mutations were AZT (T215F/Y, D67N/E); 3TC (M184V, T215F/Y, D67N/E), FTC (M184V), ABC (M184V) and TDF ( Discussion: Others mutations detected such as T215F/Y, D67N/E, K70R, and K219Q are associated with intermediate resistance to TDF, AZT, and 3TC.

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.

PMID: 30137335 2018 The Journal of antimicrobial chemotherapy

Abstract: However, the detection of RAMs by UDS with a 1% cut-off was significantly higher than that of bulk sequencing for RT codons D67N (65.4% versus 52.3%), M184V (66.2% versus 52.3%), L210W (48.9% versus 36.4%) and T215Y (57.9% versus 42.1%) and PR codons M46I (46% versus 26%), I54L (12.4% versus 3.9%), V82A (44.5% versus 29.9%) and L90M (57.7% versus 42.5%).

Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.

PMID: 30223845 2018 Virology journal

Abstract: Thymidine Analogue Mutations (TAMs) such as M41 L, K70R and T215Y were found in all the groups; the most common of the TAMs found were M41 L and T215Y.

Discussion: For the mothers who were on ART after prophylaxis in the PMTCT programme, the HIV-1 drug resistance associated mutations seen were dominated by M184 V for NRTIs and Thymidine Analogue-Associated Mutations (TAMS) including M41 L and T215Y; and K103 N with A98G for NNRTIs.

Discussion: Generally, it is known that mutations selected by TAMS confer resistance to internationally approved

PMID: 30408827 2018 PloS one

Discussion: Large transmission networks of German MSM were observed for the most frequently transmitted NRTI mutation T215S (revertant of T215Y/F), and the PI resistance mutations M46I and V82L.

Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay.

PMID: 30409215 2018 AIDS research and therapy

Result: Most of these minority drug resistance mutations were detected in the 67 cART-experienced individuals, e.g., the HIV-1 genotype of the following patients consisted of a mixture of majority and minority drug resistance mutations: patient SG79 (PR V11I 99.9%, K20I 99.9%; RT E44D 1.3%, D67N 1.1%, L100I 1.7%, M184V 84.9%, M184I 14.8%, K219Q 2.1%, INT E157Q 99.8%), patient SG86 (RT M184V 99.8%, INT L74M 97.9%, L74I 1.9%, E92Q 86

Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.

PMID: 30442114 2018 BMC infectious diseases

Table: T215Y

Discussion: show that TAM (M41 L, L210 W, and T215F/Y) and M184I/V mutations related to NRTI drug resistance increased after patients switched to the second-line regimen.

Molecular Antiretroviral Resistance Markers of Human Immunodeficiency Virus-1 of CRF01_AE Subtype in Bali, Indonesia.

PMID: 30714528 2018 Current HIV research

Discussion: Molecular marker mutations in more than 50% of treatment failure patients were M184V, T215A/Y/F, D67N/G, and M41L.

Discussion: Molecular markers of TAMs, M184V (100%), T215A/Y/F (88.2%), D67N/G (76.5%), and M41L (58.8%), were found in more than 50% of treatment failure patients.

Discussion: There are two clusters of TAMs; cluster 1 includes substitutions of M41L, L210W and T215Y, while cluster 2 of D67N, K70R, T125F and

Resistance profile of children and adolescents infected with HIV-1 in urban areas in Togo.

PMID: 30799830 2018 Medecine et sante tropicales

Abstract: The mutations associated with the most frequent NRTIs were M184V, Y181C, and T215Y.

Generalized semiparametric varying-coefficient model for longitudinal data with applications to adaptive treatment randomizations.

PMID: 27918612 2017 Biometrics

Introduction: ACTG 244 began enrollment in February 1994, and among the 289 enrollees, 284 were dispensed ZDV, of whom 57 developed T215Y/F.

Introduction: ACTG 244 enrolled subjects receiving ZDV monotherapy and monitored their HIV in plasma bi-monthly for the T215Y/F mutation.

Introduction: ACTG 244 was a randomized, double-blind trial that evaluated the clinical utility of monitoring HIV infected patients taking Zidovudine (ZDV) monotherapy for occurrence of the T215Y/F ZDV resistance mutation.

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