literature

HIV mutation literature information.

Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.

PMID: 22592583 2012 Journal of acquired immune deficiency syndromes (1999)

Result: Mutations M41L (3.7%), T215Y/F/S/D/C/E (4.0%), K103N/S (4.7%) and L90M were most prevalent.

High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lome, Togo.

PMID: 21663632 2011 Journal of the International AIDS Society

Result: Two patients had virus mutations indicative of the TAM-1 profile (M41L, L210W, T215S), and two of the TAM-2 profile (D67N, K70R, T215F, K219Q/R/E).

Presence of drug resistance mutations among drug-naive patients in Morocco.

PMID: 21087198 2011 AIDS research and human retroviruses

Abstract: The presence of DRMs was found in four (5.06%) of 91 patients; resistance mutations to NRTIs were M184V and T215I/S revertant mutations; resistance to NNRTIs was associated with K103N and resistance to PIs with V82A.

[Prevalence of primary antiretroviral resistance among HIV infected patients in Chile].

PMID: 20919475 2010 Revista medica de Chile

Abstract: Point mutations for non nucleoside reverse transcriptase inhibitors (NNRTI) were detected in 4.1% of cases (K103N in 1 patient, V179D in 2 patients), for nucleoside reverse transcriptase inhibitors (NRTI) in 8.1% of cases (T215S in 1 patient, V118I in 4 patients, M41L in 1 patient) and for protease inhibitors (PI) in 1.3% of cases.

Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.

PMID: 20628644 2010 PloS one

Introduction: We also studied so called T215 reversion mutations (T215A/C/D/E/G/H/I/L/N/S/V).

Result: We also investigated the levels of preexisting T215 reversion mutations (T215A/C/D/E/G/H/I/L/N/S/V) and found that four of five patients had preexisting levels of T215A and/or T215I that ranged from 0.05% to 0.11% (Table 3), whereas we did not detect any of the other 215 reversion mutations.

Table: T215S

Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir.

PMID: 20008905 2010 The Journal of antimicrobial chemotherapy

Result: Seven of the VF subjects at baseline had resistance mutation-containing low-abundance viral species (including one of more of the following: A62V, F77L, K70E, T215A, T215S, D67G, M184V or K219Q) with the potential to impact response to one or more study drugs.

Result: The only subject with TAMs detected at baseline who did not have detectable TAMs at failure was Subject 6, who had only a very low incidence of T215S (1/128 clones) at baseline.

Table: T215S

Analysis of the diversity of the HIV-1 pol gene and drug resistance associated changes among drug-naive patients in Burkina Faso.

PMID: 19697403 2009 Journal of medical virology

Abstract: The mutations were distributed as follows: NRTI (10.6%): M41L (n = 2), D67N (n = 2), K70K/E (n = 2), L210W (n = 1), T215S/Y (n = 2), and K219K/Q (n = 2); NNRTI (6.1%): K103K/N (n = 2), Y181C (n = 2), G190G/A (n = 1), and P236P/L (n = 1).

Genetic characterization of HIV-1 strains in Togo reveals a high genetic complexity and genotypic drug-resistance mutations in ARV naive patients.

PMID: 19460333 2009 Infection, genetics and evolution

Abstract: A total of 8 patients harbored strains with mutations associated to drug resistance: L90M (n=1), K103N (n=1), T69N (n=1), T215S (n=1), M41L (n=4).

HIV-1 pol phylogenetic diversity and antiretroviral resistance mutations in treatment naive patients from Central West Brazil.

PMID: 19682948 2009 Journal of clinical virology

Abstract: T215D/S revertant mutations were identified in 4/97 patients.

Antiretroviral drug-resistant mutations at baseline and at time of failure of antiretroviral therapy in HIV type 1-coinfected TB patients.

PMID: 19895208 2009 AIDS research and human retroviruses

Abstract: At baseline, major DRMs with respect to NNRTIs (G190GA) and TAMs (T215S and I) were observed in 3 out of 107 patients.