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 HIV mutation literature information.


  Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
 PMID: 26483513       2016       The Journal of antimicrobial chemotherapy
Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.


  HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
 PMID: 26414663       2016       AIDS research and human retroviruses
Abstract: However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively.


  Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.
 PMID: 25711326       2015       HIV medicine
Abstract: The most frequent TDR mutations observed were M41L, D67N/G/E, T215F/Y/I/S/C/D/E/V/N, 219Q/E/N/R, K103N/S, and G190A/S/E in reverse transcriptase, and M46I/L and L90M in protease.


  HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
 PMID: 26717411       2015       PloS one
Result: The TAMs M41L, D67N/E/G and K219Q/E/N/R and the T215 revertant mutations (T215C/D/E/S/I/V) were the most common non-major transmitted NRTI DRMs.


  HIV-1 subtype characteristics of infected persons living in southwestern Greece.
 PMID: 26715861       2015       HIV/AIDS (Auckland, N.Z.)
Result: The four treatment-naive cases presented with the following DRMs: I84V for PIs, K103N for NNRTIs, and T215S and K219Q for NRTIs.


  HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
 PMID: 26558396       2015       PloS one
Result: The first case included a virus with acquired K103N from a heterosexual male enrolled at Tegucigalpa and a female with transmitted K103N from San Pedro Sula (Fig 1B); the second case included two females enrolled at San Pedro Sula, one with acquired K103N and the other with transmitted K103N (Fig 1C); and the third case included two closely related, multidrug resistant viruses from heterosexual males enrolled at La Ceiba, one containing acquired M46L and T215Y and the other containing transmitted M46 and T215S (Fig 1D).


  A phylotype-based analysis highlights the role of drug-naive HIV-positive individuals in the transmission of antiretroviral resistance in the UK.
 PMID: 26355570       2015       AIDS (London, England)
Abstract: The most commonly transmitted mutations were L90M in the protease gene and K103N, T215D and T215S in reverse transcriptase.


  Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.
 PMID: 26107265       2015       PloS one
Table: T215S


  Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
 PMID: 26010948       2015       PloS one
Discussion: In this regard, the transmission of T215S mutation within a cluster of newly diagnosed MSM for 2 years has been reported by other authors.


  [HIV-1 subtype diversity and transmission clusters among men having sex with men who recently got HIV-l infection, in Zhejiang province].
 PMID: 25876868       2015       Zhonghua liu xing bing xue za zhi
Abstract: Three surveillance drug resistance mutations (M46I, T215S and G190A) were found in three samples (each sample harbored only one resistance mutation).



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