literature

HIV mutation literature information.

Emergence of Resistance in HIV-1 Integrase with Dolutegravir Treatment in a Pediatric Population from the IMPAACT P1093 Study.

PMID: 34694878 2022 Antimicrobial agents and chemotherapy

Result: Three participants had additional treatment-emergent resistance-associated reverse transcriptase substitutions of T215F/L, T215F/I/S/T and M230I/M, or M184V (n = 1 each) at PDVF.

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Method: Thymidine-analog mutations were defined as the NRTI-SDRMs M41L, D67N/G/E, K70R, L210W, T215Y/F/S/C/D/E/I/V, and K219Q/E/N/R.

Discussion: Conversely, four of the T215 revertant mutations, T215C/D/E/S had treatment/naive prevalence ratios of about 1.0 raising the question of whether these mutations will remain useful for the ongoing surveillance of clinically meaningful transmitted NRTI resistance.

Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.

PMID: 33369017 2021 HIV medicine

Abstract: Using the 2% detection threshold, individual DRMs with the highest prevalence were: PI M46IL (5.5%), RT K103NS (3.5%), RT G190ASE (3.1%), T215ISCDVEN (2.5%), RT M41L (2.2%), RT K219QENR (1.7%) and PI D30N (1.6%).

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naive HIV Patients in Southeast China.

PMID: 33679129 2021 Drug design, development and therapy

Abstract: Two samples harbored the T215S, M184V and K70E mutations related to nucleoside RTIs (NRTIs).

Table: T215S

High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.

PMID: 34025122 2021 Infectious diseases

Result: For NRTIs, these were M184VI (55.6%), T215SNY (22.2%), and K65R (18.5%).

Transmitted HIV drug resistance and subtype patterns among blood donors in Poland.

PMID: 34140600 2021 Scientific reports

Result: Transmitted drug resistance mutations (tDRM), based on WHO mutation list, were observed in one (0.6%) protease (L54M mutation), 6 (3.8%) NRTI (mutations in the codon positions: M41L, D67N, T215S/V, K219Q) and two (1.1%) (both E138K mutations) integrase seq

Discussion: As expected the most common NRTI DRMs were thymidine analog mutations, namely M41L, D67N, T215S/V, K219Q, associated with high levels of resistance to zidovudine, but also affect the abacavir and tenofovir sensitivity.

Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.

PMID: 34488793 2021 Virology journal

Result: K103N (0.42%, 10/2368), Y181C (0.21%, 5/2368), and G190A (0.21%, 5/2368) were the most common NRTI-associated mutations, and M184V (0.21%, 5/2368), L210W (0.21%, 5/2368), and T215S (0.13%, 3/2368) were the most common NNRTI-associated mutations.

Transmitted drug resistance to Tenofovir/Emtricitabine among persons with newly diagnosed HIV infection in Shenyang city, Northeast China from 2016 to 2018.

PMID: 34243716 2021 BMC infectious diseases

Discussion: It is no surprise that NNRTI-related mutations increased rapidly in China recently, and M184V/I and T215I/Y/S/D/F were the main NRTI DRMs in ART-naive and ART-treated individuals, respectively.

Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.

PMID: 31819984 2020 The Journal of antimicrobial chemotherapy

Result: Frequent NRTI DRMs included the thymidine analogue mutations M41L, L210W and T215S.

Result: Other frequently shared DRMs included: reverse transcriptase (RT) Y188L (11/175), RT T215S/C (24/175) and protease M46I (19/175), mostly at >=20% within-host frequency; and RT D67N/G/E (56/175) and RT P225H (16/175) as low-frequency variants.

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

PMID: 31922125 2020 EClinicalMedicine

Result: In NRTI mutations, T215I/Y/S/N/F/E had the highest percentage (31.2%) in subtype B, whereas M184I/V had the most predominant percentage (43.8-73.3%) in CRF01_AE and other subtypes (Table 2 and Appendix 20).

Result: The top NRTI mutations identified in ART-naive and ART-treated individuals were M184V/I (16.3% and 41.8%) and T215I/Y/S/D/F (20.9% and 9.5%), and the top NNRTI mutations were K103N/S (18.7% and 40.5%), Y181C/I (14.0% and 22.2%), and G190A/S (9.5% and 22.2%, respectively).

Discussion: Similarly, another free

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