literature

HIV mutation literature information.

Comparisons of Primary HIV-1 Drug Resistance between Recent and Chronic HIV-1 Infection within a Sub-Regional Cohort of Asian Patients.

PMID: 23826076 2013 PloS one

Abstract: Among those with recent infection, the most common RAMs to nucleoside reverse transcriptase inhibitors (NRTIs) were M184I/V and T215D/E/F/I/S/Y (1.1%), to non-NRTIs was Y181C (1.3%), and to PIs was M46I (1.5%).

Abstract: Of patients with chronic infection, T215D/E/F/I/S/Y (0.8%; NRTI), Y181C (0.5%; non-NRTI), and M46I (0.4%; PI) were the most common RAMs.

Result: <

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

PMID: 23840622 2013 PloS one

Result: (ii) K65N, which occurred in one patient receiving TDF; (iii) T69D, V75M, and V75T, which occurred in 1.3%, 2.5%, and 0.3% respectively; (iv) T215I occurred in 1.4% of patients; and (v) K219R and K219N, occurred in 1.6% and 0.9% respectively.

Increased risk of Q151M and K65R mutations in patients failing stavudine-containing first-line antiretroviral therapy in Cambodia.

PMID: 24015311 2013 PloS one

Result: The most frequently detected mutations were: M184I/V (92.3%), Y181C/I/V (47.1%), T215I/C/F/N/S (38.8%), D67E/G/N (37.3%), K103N/R/S (33.9%), and G190A/Q/S (32.5%).

Highly-sensitive allele-specific PCR testing identifies a greater prevalence of transmitted HIV drug resistance in Japan.

PMID: 24358257 2013 PloS one

Table: T215I

Differential in vitro kinetics of drug resistance mutation acquisition in HIV-1 RT of subtypes B and C.

PMID: 23056372 2012 PloS one

Abstract: RT subtype B virus isolates tended to acquire different ZDV resistance mutations (Q151M and D67N or T215Y, D67D/N and F214L) compared to subtype C (D67N, K70R, T215I or T215F).

Result: The first mutation (D67N) was replaced by T215I at day 91 (2 microM), after the virus reached a VL level comparable to that before selection.

Result: The mutation T215I (ATY or ATC) is an intermediary mutation between T215 (ACC) and T215F (TTT).

Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

PMID: 22363673 2012 PloS one

Table: T215I/T

Table: T215I

HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.

PMID: 21633285 2011 AIDS (London, England)

Result: Other NRTI-associated mutations detected included T69A/N/S (n=21), V75L, V118I and T215A/I.

Presence of drug resistance mutations among drug-naive patients in Morocco.

PMID: 21087198 2011 AIDS research and human retroviruses

Abstract: The presence of DRMs was found in four (5.06%) of 91 patients; resistance mutations to NRTIs were M184V and T215I/S revertant mutations; resistance to NNRTIs was associated with K103N and resistance to PIs with V82A.

Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.

PMID: 20628644 2010 PloS one

Abstract: CONCLUSIONS: With this highly sensitive UDPS protocol preexisting drug resistance was infrequently observed; only M184I, T215A and T215I were detected at very low levels.

Abstract: Other resistance mutations, except T215A and T215I were below the detection limit.

Introduction: Thus, only M184I, T215A and T215I were found at very low levels.

Transmission networks of drug resistance acquired in primary/early stage HIV infection.

PMID: 19005274 2008 AIDS (London, England)

Abstract: The transmission of nucleoside analogue mutations and 215 resistant variants (T215C/D/I/F/N/S/Y) declined with clustering (7.9 vs.

Result: As shown, viral variants harbouring mutations to NRTIs, including revertants at codon 215 (T215C/D/I/N/S), thymidine analogue mutations, and M184V, as well as to PIs were less frequent in clustered transmissions.

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