Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.
PMID: 29026792
2017
Iranian journal of public health
Abstract: The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results of protease revealed G73SC (13.8%) and I47VA (6.9%).
HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China.
Abstract: Among them, 7 polymorphisms (L74I, K103N, V106A, Y181C, G190A, T215I and P225H) were known to be drug resistance mutations, 7 polymorphisms (E6D, E35D, S37N, I93L, E169D, T200V and T200E were considered to be potential drug resistance mutations, and 6 polymorphisms (T39A, K43E, S68N, Q197K, T200V and E22
HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.
Result: Similarly, within NRTI SDRMs, K70ER, V75A, F77L, M184I, T215I, and K219E were only found under the 5% threshold, while D67G and M184V, although present in levels >=5% in some patients, were also mostly present as low-abundance variants <5% (0.8% vs.
Antiretroviral drug resistance mutations in naive and experienced patients in Shiraz, Iran, 2014.
Abstract: Among the 40 ART-naive patients, two mutations associated with nucleoside reverse transcriptase inhibitor (NRTI) resistance (two with Y115F and T215I) and three associated with non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance (two with G190S and Y181C, four with V179T) were found.
HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
Result: The TAMs M41L, D67N/E/G and K219Q/E/N/R and the T215 revertant mutations (T215C/D/E/S/I/V) were the most common non-major transmitted NRTI DRMs.
Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.
Abstract: Phylogenetic analysis indicated that pre-existing K103N and T215I variants had close genetic relationships with high-frequency K103N and T215I observed during treatment.
Method: According to the specificity of the primers, T215F primer cross reacted with T215L/I/ L/V, and T215Y primer with T215D/N /Y (S1 Table).
Method: The T215I-positive amplicons were similarly analyzed with amplicons spanning codon 215 to 101.
Method: To avoid possible bias by K103N and T215I mutation in the phylogenetic analysis, K103N and
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
5Result: PI and NRTI DRMs were detected by SGS only and at baseline in 2 children, ""D"" and ""E."" These were T215I (5%, n = 21 sequences) in ""D"" and the major PI DRM I50V (3%, n = 30 sequences) in ""E."" T215I is not known to confer NRTI resistance rather it is a reversion mutation of the thymidine analog mutation (TAM) T215F/Y."
8Discussion: Furthermore, despite failing AZT and LPV/r-containing therapy, T215I and T219N in RT and I50V in PR were not detected by SGS or bulk sequencing during ART for the 2 children (""D and E"
HIV mutation literature information.
PMID: 
2017
PloS one
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