Introduction: ACTG 244 began enrollment in February 1994, and among the 289 enrollees, 284 were dispensed ZDV, of whom 57 developed T215Y/F.
Introduction: ACTG 244 enrolled subjects receiving ZDV monotherapy and monitored their HIV in plasma bi-monthly for the T215Y/F mutation.
Introduction: ACTG 244 was a randomized, double-blind trial that evaluated the clinical utility of monitoring HIV infected patients taking Zidovudine (ZDV) monotherapy for occurrence of the T215Y/F ZDV resistance mutation.
Introduction: An additional reason is that the time to develop the T215Y/F mutation introduces informative censoring, and thus our analysis of the second randomization strategy that only includes subjects who did not develop the mutation avoids making a false assumption of
Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom.
Method: In this report, the term 'transmitted drug resistance mutations' (TDRMs) is used to describe (a) for pol, the presence of one or more mutations from the World Health Organisation (WHO) 2009 surveillance list 19 with the addition of E138K, a mutation known to cause resistance to the second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine, and all changes at codon T215 as they are likely to be ancestrally related to T215F or Y mutations 20; (b) for integrase, the presence of mutations from the IAS-USA 2013 list or accessory mutations reported by the Stanford HIVdb algorithm v7.0 (HIV Drug Resistance Database, Stanford University, Stanford, CA).
Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis.
Result: This decreasing trend was associated with reductions in frequency of several DR mutations including D67N, K70R, M184V, L210W, T215F, T215Y, and K219E (p<0.05; Fig 5).
Discussion: 3.1%, p<0.0001), with a significant reduction in the frequency of M184V and of most thymidine analogue mutations (TAM), including D67N, K70R, L210W, T215F, T215Y, and K219E.
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively.
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Conclusion: Analyses with subtype B RT indicated that K65R and the TAM T215F/Y are not compatible in the absence of the Q151M complex and were rarely found if Q151M or Q151M and at least two additional mutations of the complex were present.
Conclusion: Thus, a strong functional antagonism of K65R and T215F/Y in the presence of two or more additional TAMs may exist.
Conclusion: We show here, that s
Conclusion: the HIV Drug Resistance Database (http://hivdb.stanford.edu/), which give high AZT resistance mutation scores for Q151M occurring in coexistence with the TAMs T215F and M41L.
Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain.
PMID: 26921800
2016
Infection, genetics and evolution
Abstract: The most prevalent mutations for each inhibitor class were PI L90M, NRTI T215D/Y/F, and NNRTI K103N, which were also among the most prevalent resistant variants in the whole dataset.
Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.
Method: To construct an AZTR RT-containing version of pCMVDeltaR8.2, the following amino acid substitutions that confer resistance to AZT: D67N, K70R, T215F, and K219Q were introduced into an HIV reverse transcriptase (RT) gene fragment using overlap extension PCR, sequenced, and used to replace wild-type sequences between AgeI and BclI in pCMVDeltaR8.2 to produce pCBN103-18, which contains an AZT-resistant (AZTR) RT gene.
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia.
Discussion: Among them, the mutations G190S, K103N, M184V, Y181C, K101E, M41L, and T215F/Y, influencing the HIV resistance to NRTIs and NNRTIs, are observed at a high rate.
Treatment Outcomes and Resistance Patterns of Children and Adolescents on Second-Line Antiretroviral Therapy in Asia.
PMID: 27355415
2016
Journal of acquired immune deficiency syndromes (1999)
Result: NRTI mutations included >=1 TAM (40%), >=4 TAMs (10%), T215Y/F (23%), Q151M (4%), M184V (56%), K65R (2%).
Result: Of the 156 (56%) children who had available resistance testing at the time of first-line failure, mutations included M184V (82%), >=1 thymidine analog mutation (TAM; 64%), >=4 TAMs (18%), T215Y/F (43%), K65R (10%), >=1 NNRTI mutation (92%), Y181I/C (44%), G190A (33%), K103N/S (27%), and V108I (15%); 30 (19%) children had DUET weighted scores >=4 (Table 2).
Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY(R) System.
Abstract: In terms of loci, the detection rate of the alleles was greater than 97% for M41L, K65R, M184V and G190A, 91.2% for K101E/Q/P, 91.2% for T215F/Y, 89.9% for K103N/S and 80.5% for L210W.
Introduction: In this study, we established a multiplex assay for detecting the drug resistance mutations at 8 loci (M41L, K65R, K101E/Q/P, K103N/S, M184V, G190A, L210W an
HIV mutation literature information.
PMID: 
2017
Biometrics
Browser Board
Co-occurred Entities
Filtrator
ViMRT