literature

HIV mutation literature information.

Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.

PMID: 25680310 2015 Clinical microbiology and infection

Abstract: The most common TC-DRM present in >=50% of them were D67NME, T215FVY, M41L and K103N (retrotranscriptase) and L90M (protease).

The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.

PMID: 25341667 2014 Viruses

Introduction: Data from this study shows that while K65R was present in 82% of genomes without TAMs, and at low frequency in the presence of <3 TAMs; no sequences were identified with K65R, T215F/Y and >= 2 TAMs in the absence of the Q151M multi-drug resistant complex.

Introduction: Several mutations (the thymidine analog mutations, TAM) are required for high-level AZT resistance by excision, and include M41L, D67N, K70R, T215F or Y and K219E or Q.

Introduction: The association of Q151M and other Q151M complex mutations with K65R,

PMID: 24145874 2014 Clinical infectious diseases

Abstract: Three clusters showed evidence of reversion of K103N or T215Y/F.

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

PMID: 24174331 2014 Proteins

Result: this putative effect may be analogous to the impact of L210W accompanying the T215Y/F mutation to enhance ATP binding.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Discussion: Results from the HIV-1 drug resistance mutation research by the International AIDS Society-USA (updated in March 2013) have revealed that PI resistance mutation sites are L10I, K20M, V32I, M36I, M46I/L, I47V/A, I50V, Q58E, A71V, G73S, V82A/F/T, I84V, L89V,L90M; NRTIs resistance mutations are M41L, A62V,

PMID: 24667336 2014 Antiviral research

Abstract: Thymidine analogue resistance mutations (TAMs) in HIV-1 reverse transcriptase (RT) associate in two clusters: (i) TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F).

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Result: We also found a case of a transitional mutation, T215S, which is detected in isolates that eventually go on to develop the NRTI drug resistance mutations T215Y and T215F.

Table: T215F

[Analysis of HIV genotypic drug resistance among pediatric HIV/AIDS cases with virological failure after free antiretroviral therapy in Yunnan province].

PMID: 24854905 2014 Zhonghua yi xue za zhi

Abstract: The prevalent mutations associated with drug resistance were M184V/I, K103N, T215F/Y, G190A, Y181C and K101E at the frequencies of 52.1% (38/73), 30.1% (22/73), 21.9% (16/73), 20.5% (15/73), 15.1% (11/73) and 12.3% (9/73) respectively.

High level of HIV-1 resistance in patients failing long-term first-line antiretroviral therapy in Mali.

PMID: 24855120 2014 The Journal of antimicrobial chemotherapy

Abstract: The treatment duration, median number of NRTI and NNRTI mutations and some reverse transcriptase mutations (T215Y/F/N, L210W, L74I, M41L and H221Y) were associated with the VL at virological failure.

Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.

PMID: 25397495 2014 Journal of the International AIDS Society

Abstract: However, thymidine analogue resistance mutations (TAMs) determined two distinct genotypic profiles in the HIV-1 reverse transcriptase: TAM1: M41L, L210W and T215Y, and TAM2: D67N, K70R, K219E/Q, and T215F.

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