literature

HIV mutation literature information.

[The efficacy of antiviral therapy and drug resistance analysis among HIV/AIDS patients with heroin addiction in Guangxi Zhuang Autonomous Region].

PMID: 25573121 2014 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Abstract: Among the patients who received antiviral treatment, the mutation frequency of M184V/I, T215Y/F, L210W and T69N/S in heroin abuser group were significantly higher than that in never using drug group (14.9% (11/74) vs 4.4% (3/68), 12.2% (9/74) vs 1.5% (1/68), 12.2% (9/74) vs 1.5% (1/68) and 10.8% (8/74) vs 1.5% (1/68) respectively) (P < 0.05).

Treatment-naive individuals are the major source of transmitted HIV-1 drug resistance in men who have sex with men in the Swiss HIV Cohort Study.

PMID: 24145874 2014 Clinical infectious diseases

Abstract: Three clusters showed evidence of reversion of K103N or T215Y/F.

Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

PMID: 24174331 2014 Proteins

Result: this putative effect may be analogous to the impact of L210W accompanying the T215Y/F mutation to enhance ATP binding.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Discussion: Results from the HIV-1 drug resistance mutation research by the International AIDS Society-USA (updated in March 2013) have revealed that PI resistance mutation sites are L10I, K20M, V32I, M36I, M46I/L, I47V/A, I50V, Q58E, A71V, G73S, V82A/F/T, I84V, L89V,L90M; NRTIs resistance mutations are M41L, A62V,

PMID: 24667336 2014 Antiviral research

Abstract: Thymidine analogue resistance mutations (TAMs) in HIV-1 reverse transcriptase (RT) associate in two clusters: (i) TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F).

HIV-1 drug mutations in children from northern Tanzania.

PMID: 24729604 2014 The Journal of antimicrobial chemotherapy

Result: We also found a case of a transitional mutation, T215S, which is detected in isolates that eventually go on to develop the NRTI drug resistance mutations T215Y and T215F.

Table: T215F

[Analysis of HIV genotypic drug resistance among pediatric HIV/AIDS cases with virological failure after free antiretroviral therapy in Yunnan province].

PMID: 24854905 2014 Zhonghua yi xue za zhi

Abstract: The prevalent mutations associated with drug resistance were M184V/I, K103N, T215F/Y, G190A, Y181C and K101E at the frequencies of 52.1% (38/73), 30.1% (22/73), 21.9% (16/73), 20.5% (15/73), 15.1% (11/73) and 12.3% (9/73) respectively.

High level of HIV-1 resistance in patients failing long-term first-line antiretroviral therapy in Mali.

PMID: 24855120 2014 The Journal of antimicrobial chemotherapy

Abstract: The treatment duration, median number of NRTI and NNRTI mutations and some reverse transcriptase mutations (T215Y/F/N, L210W, L74I, M41L and H221Y) were associated with the VL at virological failure.

The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.

PMID: 25341667 2014 Viruses

Introduction: Data from this study shows that while K65R was present in 82% of genomes without TAMs, and at low frequency in the presence of <3 TAMs; no sequences were identified with K65R, T215F/Y and >= 2 TAMs in the absence of the Q151M multi-drug resistant complex.

Introduction: Several mutations (the thymidine analog mutations, TAM) are required for high-level AZT resistance by excision, and include M41L, D67N, K70R, T215F or Y and K219E or Q.

Introduction: The association of Q151M and other Q151M complex mutations with K65R,

PMID: 25314293 2014 PloS one

Result: DR mutations were found at codons M41L (n = 22), K65R (n = 3), K70R (n = 10), K103N (n = 7), M184V (n = 21) and T215Y/F (n = 22) in 40 specimens (Table 2).

Table: T215F

Figure: wild type; 2, M41L-TTG; 3, M41L-CTG; 4,

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