Analysis of generalized semiparametric mixed varying-coefficients models for longitudinal data.
PMID: 31827312
2019
The Canadian journal of statistics
Introduction: ACTG 244 enrolled HIV-infected patients receiving zidovudine (ZDV) monotherapy, and monitored them every eight weeks for occurrence of the 215 (T215Y/F) ZDV resistance mutation.
Introduction: ACTG 244 enrolled HIV-infected patients taking zidovudine (ZDV) monotherapy and monitored their HIV in plasma every eight weeks for presence of the T215Y/F ZDV resistance mutation.
Introduction: Let S1 be the time between the dates of study entry and the first randomization triggered by occurrence of the T215Y/F mutation, such that U1(t) = t - S1 is the follow-up time starting at the date of the first randomization.
Introduction: Of 289 enrolled participants, 5 were randomized but went off study before taking any medication, 284 were dispensed ZDV, and 57 de
Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia.
Discussion: These variants develop from strains containing T215Y/F mutations, primarily selected under the stavudine (d4T) and zidovudine (AZT) treatment and tend to persist for many years.
Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon.
Result: Eleven (25%, 11/44) of the RTRM were thymidine analogue mutations (T215FY [2.5%, 6/239], K70R [1.7%, 4/239] and 0.8% (2/239) each of D67N, L210W, M41L, and K219Q/E (Fig 2).
Result: The mutational pattern, D67N-M41L-M184V-L210W-T215F/Y was the most resistant conferring HLR to all drugs in the class, except tenofovir that showed intermediate resistance (IR) (Table 2).
Table: T215F/Y
Table: T215F
Discussion: The second prevalent resistance-associated mutations were PMID: 31702525
2019
Current HIV research
Abstract: The phylogenetic analyses of the amplified region of pol gene indicated that all of the 15 HIV-1-infected pediatric patients were infected by CRF35_AD, and a total of 13.3% (2/15) of these children were infected with HIV-1 variants with SDRMs (one child harbored two related SDRMs [D67N, V179F], and another child had three related SDRMs [M184V, T215F, and K103N]), according to the last algorithm of the WHO.
Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients.
PMID: 31660328
2019
Open forum infectious diseases
Method: Information on thymidine analogue mutations (TAMs; M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) before the switch to ABC/3TC/DTG also was obtained.
HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting.
PMID: 31117863
2019
Journal of the International Association of Providers of AIDS Care
Table: T215F
Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam.
Abstract: In thymidine analogue mutations, K70R mutation was the most common (37.2%), followed by D67N, T215F and T69N mutations (27.9%, 27.9% and 25.6%, respectively).
Discussion: TAMs occur in different patterns: type 1 includes M41L, L210W and T215Y (14%, 11.6% and 4.7% prevalence, respectively, in our study), and type 2 includes K70R, D67N T215F and K219Q/E (37.2%, 27.9%, 27.9% and 14% prevalence, respectively, in our study).
Discussion: The accumulation of other mutations observed included TAMs (including M41L, L210W,
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Result: Pre-existing NRTI-R substitutions were observed in 16% (89/543) of BIC/FTC/TAF-treated participants; the most frequently detected substitutions were M184V/I in 10% (54/543) and thymidine analogue mutations (TAMs; M41L, D67N, K70R, L210W, T215Y/F and K219Q/N/E/R) in 8.8% (48/543).
Table: T215F/Y
Table: T215Y/F
Distinct Pattern of Thymidine Analogue Mutations with K65R in Patients Failing Tenofovir-Based Antiretroviral Therapy.
PMID: 29084434
2018
AIDS research and human retroviruses
Introduction: Based on significant previous research of DRMs, TAMs have been described to associate into one of two distinct pathways: TAM-1 (M41L, L210W, T215Y) or TAM-2 (D67N, K70R, T215F, K219E/Q).
Introduction: In viruses lacking K65R, the TAMs observed included a broader array of primarily TAM-2, including K219E, D67N, K70R, T215F, and K219Q, and in one patient with TAM-1, T215Y.
Introduction: This was not true of other TAMs present in patients on 1L TDF, such as PMID: 29698470
2018
PloS one
Discussion: In contrast to T215Y/F, T215 revertants show no reduction in transmission fitness.
Discussion: The T215 revertants appear in the absence of drug pressure from T215Y/F mutations that were initially selected under zidovudine treatment.
HIV mutation literature information.
PMID: 
2019
The Canadian journal of statistics
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