Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States.
Result: Given the high frequency of M184V/I detected in all samples (28%, 56/197), these mutations were combined with thymidine-analog mutations (TAMs; ie, M41L, L210W, T215Y, D67N, K70R, T215F, K219Q/E) for analysis.
Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data.
Result: The second study subject, also a Romanian citizen living in Cyprus, was also infected with a sub-subtype F1strain dual-class RT and PI resistant strain carrying D67N, K70R, M184V, T215F, Y181C, M46L, I54V and V82F mutations associated with drug resistance.
HIV-1 transmitted drug resistance in Slovenia and its impact on predicted treatment effectiveness: 2011-2016 update.
Result: NRTI resistance-associated mutations found in this population included M184 V (n = 3, 6.67%), M41 L (n = 2, 4.44%), T215F (n = 2, 4.44%), L74F/V (n = 2, 4.44%), D67G (n = 1, 2.22%) and K70Q (n = 1, 2.22%) (Figure1).
Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.
Discussion: TDF was used in the second-line program; the mutations associated with resistance to TDF were K65R, TAM (M41 L, K70R, L210 W, T215F), D67N, K70E, and Y115F.
Discussion: The K65R mutation causes intermediate/high-level resistance to TDF; use of TAMs (M41 L,
Discussion: show that TAM (M41 L, L210 W, and T215F/Y) and M184I/V mutations related to NRTI drug resistance increased after patients switched to the second-line regimen.
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.
Discussion: Generally, it is known that mutations selected by TAMS confer resistance to internationally approved NRTIs; examples of such TAMS encountered in the study are M41 L, D67N, K70R, L210 W, T215Y/F and K219Q/E.
Increasing proportions of HIV-1 non-B subtypes and of NNRTI resistance between 2013 and 2016 in Germany: Results from the national molecular surveillance of new HIV-diagnoses.
Discussion: Large transmission networks of German MSM were observed for the most frequently transmitted NRTI mutation T215S (revertant of T215Y/F), and the PI resistance mutations M46I and V82L.
HIV-1 infection among crack cocaine users in a region far from the epicenter of the HIV epidemic in Brazil: Prevalence and molecular characteristics.
Discussion: T215C is considered a revertant mutation that do not reduce NRTI susceptibility but indicate that this virus population once contained T215Y/F mutations.
Discussion: This mutation suggests that the patient may have once harbored a majority virus population with T215Y/F.
Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.
PMID: 29977795
2018
African journal of laboratory medicine
Result: Other minority mutations including M41L, A62V, D67N, T69D, V75M, T215F and K219E were found in one sample each.
HIV mutation literature information.
PMID: 
2018
Clinical infectious diseases
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