literature

HIV mutation literature information.

Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.

PMID: 22592583 2012 Journal of acquired immune deficiency syndromes (1999)

Result: Mutations M41L (3.7%), T215Y/F/S/D/C/E (4.0%), K103N/S (4.7%) and L90M were most prevalent.

New trends of primary drug resistance among HIV type 1-infected men who have sex with men in Liaoning Province, China.

PMID: 21417755 2011 AIDS research and human retroviruses

Abstract: Included were V32I (0.5%), M46I (2.0%), L90M (2.0%), T215C (0.5%), and Y188L (0.5%).

Abstract: Only one case carried resistance mutations to all three drug classes (L90M, L10I, and A71T to PI; T215C to NRTI; and Y188L to NNRTI).

Emerging transmitted drug resistance in treatment-naive human immunodeficiency virus-1 CRF06_cpx-infected patients in Estonia.

PMID: 20964489 2011 Scandinavian journal of infectious diseases

Abstract: A total of 2.8% of sequences harboured mutations indicating nucleoside/nucleotide reverse transcriptase inhibitor resistance (M41L, M184V, M184I, T215C and T215D), 2.1% non-nucleoside reverse transcriptase inhibitor resistance (K103N, P225H) and 2.8% protease inhibitor resistance (M46I, L90M).

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naive subjects in the CASTLE study.

PMID: 20532178 2010 PloS one

Table: T215C

Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.

PMID: 20380480 2010 AIDS research and human retroviruses

Abstract: In the four FPV/r-treated VFs, baseline HIV TAMs combinations and/or PI mutations were detected in one by PG at VF (RT: L210W + T215C; PR: M46I + L76V) and three others by CA alone (RT: L210W + T215Y; RT: M41L; RT: K65R + K70R; PR: I47V); all four had study drug-associated mutations (CA detecting more HIV-1 resistance mut

Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.

PMID: 20628644 2010 PloS one

Introduction: We also studied so called T215 reversion mutations (T215A/C/D/E/G/H/I/L/N/S/V).

Result: We also investigated the levels of preexisting T215 reversion mutations (T215A/C/D/E/G/H/I/L/N/S/V) and found that four of five patients had preexisting levels of T215A and/or T215I that ranged from 0.05% to 0.11% (Table 3), whereas we did not detect any of the other 215 reversion mutations.

Table: T215C/D

Transmitted antiretroviral drug resistance among acute and recent HIV infections in North Carolina from 1998 to 2007.

PMID: 19704170 2009 Antiviral therapy

Result: Seven recently infected subjects harbored T215C or T215D revertant mutations, which represent the first back-mutation away from T215Y.

HIV type-1 clade C resistance genotypes in treatment-naive patients and after first virological failure in a large community antiretroviral therapy programme.

PMID: 19578237 2009 Antiviral therapy

Discussion: The two mutations that are likely to reduce susceptibility to NRTIs if transmitted, T215C and M41L, were not seen in either the naive or non-naive groups.

Transmission networks of drug resistance acquired in primary/early stage HIV infection.

PMID: 19005274 2008 AIDS (London, England)

Abstract: The transmission of nucleoside analogue mutations and 215 resistant variants (T215C/D/I/F/N/S/Y) declined with clustering (7.9 vs.

Result: As shown, viral variants harbouring mutations to NRTIs, including revertants at codon 215 (T215C/D/I/N/S), thymidine analogue mutations, and M184V, as well as to PIs were less frequent in clustered transmissions.

Minority human immunodeficiency virus type 1 variants in antiretroviral-naive persons with reverse transcriptase codon 215 revertant mutations.

PMID: 18715933 2008 Journal of virology

Abstract: T215 revertant mutations such as T215C/D/E/S that evolve from the nucleoside reverse transcriptase (RT) inhibitor mutations T215Y/F have been found in about 3% of human immunodeficiency virus type 1 (HIV-1) isolates from newly diagnosed HIV-1-infected persons.

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