Discussion: T215C is considered a revertant mutation that do not reduce NRTI susceptibility but indicate that this virus population once contained T215Y/F mutations.
HIV-1 transmitted drug resistance in Slovenia and its impact on predicted treatment effectiveness: 2011-2016 update.
Result: Specifically, the first Slovenian sequence, with the T215D mutation, was found most closely related to a set of sequences carrying T215C obtained from a US citizen.
Decreasing prevalence of transmitted drug resistance among ART-naive HIV-1-infected patients in Iceland, 1996-2012.
Abstract: Six patients harbouring T215C/D, were linked in a supported phylogenetic cluster.
Abstract: The most frequent NRTI mutation detected was T215C/D (n=7, 5.7%).
Result: The time to the most recent common ancestor of the cluster harbouring (T21
Result: Thymidine analogue 215 revertant mutants (T215C/D), that cause low-level resistance to azidothymidine (AZT) and stavudine (d4T), dominated the NRTI mutations detected (n = 7; 6%).
Figure: The grey shaded area represents the monophyletic cluster with TDR mutation (T215C/D).
Discussion: Previous reports in other European countries described the same mutation (T215C/D) circulating domestically.
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively.
From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults.
Result: The TAMs M41L, D67N/E/G and K219Q/E/N/R and the T215 revertant mutations (T215C/D/E/S/I/V) were the most common non-major transmitted NRTI DRMs.
Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.
Abstract: The most frequent TDR mutations observed were M41L, D67N/G/E, T215F/Y/I/S/C/D/E/V/N, 219Q/E/N/R, K103N/S, and G190A/S/E in reverse transcriptase, and M46I/L and L90M in protease.
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Method: Thymidine-analog mutations (TAMs) were defined as the NRTI SDRMs M41L, D67N/G/E, K70R, L210W,
Result: Of the 34 NRTI SDRMs, 16 occurred in >=0.1% of the 50,870 viruses from all regions: most commonly M184V, the TAMs (M41L, D67G/N, K70R, L210W, T215F/Y, K219E/Q), the T215 revertants (T215C/D/E/S), T69D, and F77L.
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
HIV mutation literature information.
PMID: 
2018
PLoS medicine
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