literature

HIV mutation literature information.

HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naive and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes.

PMID: 27119150 2016 PloS one

Discussion: Thus, the impact of TAMs need to be better evaluated in coming years since HIV-infected subjects with mutations M184V alone, P119S/T165A/M184V combined or T69 insertion complex, including T210W and T215Y, may have significantly decreased susceptibility to the novel drug Ed4T.

Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.

PMID: 25926858 2014 AIDS research and therapy

Table: T165A/E

From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-Festinavir.

PMID: 23092278 2013 Current pharmaceutical design

Introduction: Could the previously observed 130-fold resistance of the P119S/T165A/M184V virus to 4'-ethynylstavudine be due to additional mutations in the RT and/or outside the RT sequence, or that this virus is either difficult to recover from storage due to a poor replication capacity? Based on recent studies and the structural modeling of interaction of HIV RT-primer complex and 4'-Ed4TTP, a virus with a high degree of resistance to 4'-ethynylstavudine (e.g., more that 50-fold resistance, highly resistant to 4'-ethynylstavudine) will be difficult to develop.

Introduction: When the previous HIV resistant strain (P119S/T165A/M184V), with 130-fold resistance to 4'-ethynylstavu

Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.

PMID: 19704131 2009 Antimicrobial agents and chemotherapy

Abstract: M184V may be the primary resistance-associated mutation of 4'-Ed4T, and P119S and T165A are secondary mutations.

Abstract: Previous in vitro selection for 4'-Ed4T-resistant viral strains revealed M184V and P119S/T165A/M184V mutations on days 26 and 81, respectively; M184V and P119S/T165A/M184V conferred 3- and 130-fold resistance to 4'-Ed4T, respectively.

Abstract: The P119S/M184V and T165A/M184V variants showed about fourfold resistance to 4'-Ed4

Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.

PMID: 16048947 2005 Antimicrobial agents and chemotherapy

Abstract: Analysis of 4'-Ed4T-resistant HIV-1 obtained through in vitro selection revealed that the virus was also resistant to 3TC and had two amino acid mutations (P119S and T165A) in addition to the M184V mutation.

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