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 HIV mutation literature information.


  Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction.
 PMID: 28484443       2017       Frontiers in microbiology
Abstract: In this study, HIV-1 infected patients (n = 120) from North India revealed Ser46Phe (20%) and Ser61Arg (2%) mutations in the Tat variants with a strong interaction toward TAR leading to enhanced transactivation activities.
Abstract: Molecular dynamics simulation data verified that the variants with this mutation had a higher binding affinity for TAR than both the wild-type Tat and other variants that lacked Ser46Phe and Ser61Arg.
Result: In this study, CD4 counts were follow-up for 6 months for HIV-1 infected patients (n = 15) which included: group 1 was consisted of HIV-1 infected patients (n = 9) lacking


  In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity.
 PMID: 28848502       2017       Frontiers in microbiology
Result: TatN12 (subtype C) has Leu35Pro and Gly44Ser mutations but lacked Ser46Phe, TatD60 (subtype C) has Glu9Lys, Ser46Phe a
Result: In order to check the effect of additional mutations Glu9Lys and Ser61Arg in TatD60, docking was performed in comparison to wild type Tat C.
Result: Mutation Ser61Arg results in more compact binding of TAR as Arg61 is making a hydrogen bond with C19 and A20 of TAR, suggest that Ser61Arg may have also a critical role in higher binding affinity of Tat and TAR binding.



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