literature

HIV mutation literature information.

Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction.

PMID: 28484443 2017 Frontiers in microbiology

Result: TatVT6 showed a slightly lower ubiquitination than wild-type TatC while TatD60 showed less ubiquitination indicating that Ser46Phe and Ser61Arg could stabilize Tat protein (Figures 4A,B), though it is not known if Ser46 and Ser61 are targets for ubiquitination.

Result: The binding affinity of TatN12 to TAR was less than wild-type TatC-TAR complex but not significantly; whereas the TatD60 variant carrying Ser46Phe showed significantly higher (

Discussion: Correlating Tat variants, especially variants with Ser46Phe, with the course of the disease, as well as response to ART, would provide molecular and clinical insights to managing HIV-1 patients in North India.

In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity.

PMID: 28848502 2017 Frontiers in microbiology

Introduction: Natural mutant Ser46Phe exhibited more hydrogen bond interactions with TAR than the wild type Tat (that lacked

Result: TatD60 (Ser46Phe) showed relatively higher binding to TAR than TatC and other Tat variants.

Result: TatN12 (subtype C) has Leu35Pro and Gly44Ser mutations but lacked Ser46Phe, TatD60 (subtype C) has Glu9Lys, Ser46Phe and Ser61Arg mutations, and TatVT6 is a B/C recombinant but lacked Ser46Phe.

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