literature

HIV mutation literature information.

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.

PMID: 29792216 2018 Retrovirology

Abstract: Pseudotyped HIV-1 with Tat S16E mutation replicated well, and HIV-1 Tat S46E-poorly, but no live viruses were obtained with Tat S16A or Tat S46A mutations.

Abstract: TAR RNA binding was affected by Tat Ser-16 alanine mutation.

Figure: 293T cells were co-transfected with pCI-His-hUbi pla

Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1.

PMID: 20529865 2010 The Journal of biological chemistry

Result: The S16A

Result: The viral entry assay indicated that the entry levels of S16A/P17A and WT were the same because the amounts of S16A/P17A CA protein in subcellular fractions were very similar to that of WT CA protein.

Result: These results suggest that the infectivity defect of the S16A/P17A variant is linked to a dysfunction of the uncoating process.

Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.

PMID: 17083724 2006 Retrovirology

Result: HIV-1 transcription induction by the Tat S16A mutant was approximately 75% that of WT Tat.

Result: Neither S16A nor S46A mutants of Tat efficiently induced HIV-1 viral production.

Result: the Tat S16A mutant and Tat S46A mu

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