literature

HIV mutation literature information.

HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.

PMID: 29844604 2018 Scientific reports

Result: Global sequence analysis showed that the most frequent amino acid substitutions in RT were S162C (29.4%), T200A (35.3%), M184V (32.3%), L214F (67.6%), I135T (55.9%), D177E (26.5%) and E122K (44.1%), and the most in PR were V15I (41.2%), M36I (38.2%) and E35D (23.5%).

Discussion: The other substitutions found in co-infected patients, E122K (44.1%), T200A (35.3%), S162C (29.4%) and D177E (26.5%) have been previously reported in studies with HIV mono-infected patients.

Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.

PMID: 25674767 2015 Viruses

Table: S162C

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Abstract: Polymorphism mutation sites with mutation rates in the RT region higher than 60.0% were: I135A/L/M/R/T/V 93.5%, T200A/E/I/P/V 89.7%, Q278E/K/N/T 88.8%, S162C/Y 82.2%, and K277R/S 66.4%.

Result: The sites with mutation rates higher than 60.0% included: I135A/L/M/R/T/V 93.5% (100/107), among which I135V was 80.4% (86/107); T200A/E/I/P/V 89.7% (96/107), among which T200A was 81.3% (87/107); Q278E/K/N/T 88.8% (95/107), among which

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.

PMID: 25575025 2014 Retrovirology

Table: S162C

Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.

PMID: 24015196 2013 PloS one

Table: S162C

Polymorphic mutations associated with the emergence of the multinucleoside/tide resistance mutations 69 insertion and Q151M.

PMID: 22027876 2012 Journal of acquired immune deficiency syndromes (1999)

Abstract: Frequencies of 8 polymorphic mutations (K43E, V60I, S68G, S162C, T165I, I202V, R211K, F214L) were significantly different between groups.

Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

PMID: 22363673 2012 PloS one

Table: S162C/Y

Genetic diversity and drug resistance of HIV type 1 circulating recombinant Form_BC among drug users in Guangdong Province.

PMID: 19698024 2009 AIDS research and human retroviruses

Abstract: E53D (97%), I135V/T/R (81%), S162C (94%), Q207E (100%), and R211K (97%) were primarily in CRF_08BC subtypes and D121Y/H (97%) were primarily in CRF_07BC.

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