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HIV-M: R953C
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The DNA
Polymerase
Gamma
R953C
Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity.
PMID:
27381400
2016
Antimicrobial agents and chemotherapy
Abstract:
The
R953C
mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to the wild type.
Abstract:
The
R953C
Pol
-gamma mutant binding affinity for dCTP is 8-fold less than that of the wild type.
Abstract:
We found a heterozygous
C2857T
mutation (
R953C
) in
polymerase
gamma (
Pol
-gamma) in an
HIV-infected
patient with mitochondrial toxicity.
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R953C
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2016
Abstract
27381400
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HIV mutation literature information.
PMID: 
2016
Antimicrobial agents and chemotherapy
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Co-occurred Entities
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