Result: Gag S126G, Nef T80D, and Nef R71K mutations did not accumulate in HLA-B*35:01+ Japanese individuals, whereas Nef Y135F was found in 6
Result: A previous study had described 2 HLA-A*11:01-associated polymorphisms; Gag S126G and Nef T80D, an HLA-C*07:02-associated polymorphism Nef R71K, and an HLA-A*24:02-associated polymorphism Nef Y135F in Japanese donors (Supplementary Table 2).
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.
Abstract: A dominant R71K mutation in the Nef71-79 occurred in those with HLA-B*07:02 but not B*42:01/02 or B*81:01.
Result: Despite distinct selection pressure at position 1 of RM9-Nef by HLA-B*07:02 (R71K) (Figure 2F) (Table 1), peptide residue Arg1 was in a similar conformation in all 4 HLAIs (Figure 4A).
Result: HLA-B*07:02 expressing individuals exhibited strong selection at P1 in the epitope (R71K: 41%, P = 7x10-5), whereas HLA-B*81:01 expressing individuals showed selection of variants at P6 of the epitope (L76V/T/I, L76X, P = 2x10-43) with no selection mediated by HLA-B*42:01 and HLA-B*42:02 on this RM9-Nef epitope (Figure 2F) (Table 1).
HIV mutation literature information.
PMID: 
2018
EBioMedicine
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