A longitudinal analysis of immune escapes from HLA-B*13-restricted T-cell responses at early stage of CRF01_AE subtype HIV-1 infection and implications for vaccine design.
Discussion: Some mutations within epitopes have been reported to reduce viral replication capacity, such as R264K within the B*27-restricted KK10 epitope and T242N within the B*57-restricted TW10 epitope.
Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.
Abstract: The described compensatory mutations L268M and S173A observed in R264K viruses reconstituted the capsid-uncoating half-time.
Abstract: The frequently occurring HLA-B57- and HLA-B27-associated CTL escape mutations T242N and R264K resulted in delayed capsid uncoating, suggesting modulation of capsid stability.
Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.
Discussion: In the case of KK10 epitope restricted by HLA-B*2705, Leu268Met was an early mutation affecting TCR recognition and the ultimate mutations such as Arg264Lys disrupting antigen presentation follow later.
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.
PMID: 11157057
2001
The Journal of experimental medicine
Abstract: Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.
Discussion: The results presented here indicate that in subtype B viruses, if the R264K mutation is to
Discussion: We have described five HLA-B27 carrying HIV-infected patients, four of whom have acquired the same (R264K) escape mutation in gag.
Discussion: We have shown that the R264K mutation is strongly associated with a second change L268M and that the acquisition of this doubly modified epitope does not appear to result from simple linkage between the mutations at sites 264 and 268.
HIV mutation literature information.
PMID: 
2022
BMC immunology
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