Abstract: Survival analysis showed an accelerated disease progression of individuals infected with HIV-1 carrying arginine or asparagine at position 8 or 157 in Nef, respectively, or the R178G Nef mutation.
Abstract: The 8R, 157N and R178G Nef mutations were shown to have an effect on disease progression.
Abstract: The majority of these Nef mutations had no significant effect on HIV-1 pathogenesis and only the 8R, 157N and R178G mutations were associated with disease course.
Method: The S163C, R178G and double mutants were created from NL4-3 Nef with site-directed mutagenesis.
HIV mutation literature information.
PMID: 
2021
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