Result: We aimed to determine whether the Q563R-mediated effects on Env conformation affected neutralization by the rare bNAbs targeting the gp41 region.
Figure: (B) Middle panel indicates the effect of the Q563R change in disrupting the six-helix bundle, resulting in an infectivity defect.
Figure: A single-residue change in the gp41 region (Q563R) of Env E1 is responsible for the increased infection observed speci
Discussion: Indeed, Env E1 is divergent from Env NE1 at residues 605, 621 and 648 in gp41 (S4 Fig), which may serve to help restore some of the Q563R-mediated defects.
HIV mutation literature information.
PMID: 
2020
PLoS pathogens
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