Discussion: It was also found that the PDR rate did not significantly differ among the three main subtypes (CRF07_BC, CRF08_BC and CRF01_AE); however, in a previous study, HIV-1 CRF07_BC showed distinctive resistance evolution pathways in which the mutations K103N, Q197K, V179D and Y188L were the major resistance mutations.
Polymorphisms and Mutational Covariation Associated with Death in a Prospective Cohort of HIV/AIDS Patients Receiving Long-Term ART in China.
Abstract: Among them, 7 polymorphisms (L74I, K103N, V106A, Y181C, G190A, T215I and P225H) were known to be drug resistance mutations, 7 polymorphisms (E6D, E35D, S37N, I93L, E169D, T200V and T200E were considered to be potential drug resistance mutations, and 6 polymorphisms (T39A, K43E, S68N, Q197K, T200V and E22
Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.
[Resistance evolutionary pathway analysis of HIV-1 CRF_07BC reverse transcriptase].
PMID: 24969455
2014
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Abstract: CONCLUSION: HIV-1 CRF_07BC showed distinctive resistance evolutionary pathway, the mutations K103N,Q197K,V179D and Y188L were the major resistance mutations, and different resistance evolutionary pathways were observed between HIV-1 CRF_07BC and B subtype.
Abstract: RESULTS: The major resistance mutations for CRF_07BC were identified including K103N, Q197K, V179D and Y188L.
Mutation covariation of HIV-1 CRF07_BC reverse transcriptase during antiretroviral therapy.
PMID: 23788482
2013
The Journal of antimicrobial chemotherapy
Abstract: Twelve significant covariation pairs were found between five treatment-associated mutations (K103N, M184V, Q197K, G190A and Y181C) and nine overlapping polymorphisms (A36E, D39N, Y121H, D123E, R135I, T200A, R277K, L283I and D291E).
HIV mutation literature information.
PMID: 
2019
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