Development and evaluation of an oligonucleotide ligation assay for detection of drug resistance-associated mutations in the human immunodeficiency virus type 2 pol gene.
PMID: 17329450
2007
Journal of clinical microbiology
Abstract: In this study, we designed oligonucleotide probes to detect the Q151M mutation, associated with phenotypic resistance to zidovudine, didanosine, zalcitabine, and stavudine, and the M184V mutation, associated with phenotypic resistance to lamivudine and emtricitabine, in HIV-2.
Abstract: OLA results were compared with sequencing to give high concordances of 98.4% (Q151M) and 97.5% (M184V).
Abstract: The overall sensitivity of the assay was 98.8%, with 99.2% for Q151M and 98.4% for M184V.
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
PMID: 17403997
2007
Antimicrobial agents and chemotherapy
Abstract: For non-ATP-dependent discrimination toward DOT-TP, high levels of resistance were found for RT bearing the Q151M mutation with family mutations, while RT bearing only the M184V or the Y115F mutation conferred no resistance to DOT-TP.
Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT.
Abstract: Over 18 months, no patient developed multinucleoside resistance (Q151M or T69 insertions) and plasma viral loads were stable (median +0.04 log10 copies/ml).
Chemical system biology based molecular interactions to identify inhibitors against Q151M mutant of HIV-1 reverse transcriptase.
Abstract: In 3 of the 28 patients (10.7%), the Q151M complex amino acid substitutions were identified.
Abstract: TDF-containing regimens reduced HIV-1 viremia in two of the three children carrying the Q151M complex.
Abstract: These data suggest that the Q151M could be prevalent in pediatric patients with long-term NRTI monotherapy and/or dual NRTI regimens and that HAART regimens containing TDF may be meritorious in such patients.
Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase.
PMID: 17496561
2007
Journal of acquired immune deficiency syndromes (1999)
Abstract: The Delta70 mutation also increased fitness of Hxb2 wild-type and 74V and Q151M mutants.
Abstract: The Delta70, L74V, and Q151M mutations were introduced into Hxb2 RT by site-directed mutagenesis and expressed in HIV-1 recombinants.
Abstract: We identified a deletion at codon 70 (Delta70) of HIV-1 reverse transcriptase (RT) occurring together with L74V and Q151M mutations in a sample from a tenofovir (TFV)- and abacavir (ABC)-treated patient with extensive prior antiretroviral treatment.
HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
Abstract: Patterns of RT covariation were dominated by the distinct clustering of Type I and Type II thymidine analog mutations and the Q151M-associated mutations.
Abstract: However, both the K65R and Q151M mutations show decreased excision, which would confer greater stability on the terminated primer.
Abstract: The Q151M and K65R mutations appear to cause decreased inhibition by DOT-TP.
Chemical system biology based molecular interactions to identify inhibitors against Q151M mutant of HIV-1 reverse transcriptase.
PMID: 17567542
2007
Infection, genetics and evolution
Abstract: The original isolate carried the MNR mutations S68G, V75I, F77L, F116Y and Q151M, the lamivudine mutation M184V, the NNRTI mutation K103N and the yet unreported K70S.
[Prevalence of resistance to antiretroviral drugs in Spain].
PMID: 17692254
2007
Anales de pediatria (Barcelona, Spain
Abstract: NAMs were observed in 94 % of the patients in this group, and one child showed the Q151M mutation.
Abstract: NAMs were observed in all patients in this group, and Q151M was found in three children.
Abstract: Nucleoside-associated mutations (NAMs) were found in 10 of these patients and the Q151M multiresistance mutation was found in two.
Abstract: One child showed three NAMs and another showed Q151M.
Polymorphism and drug selected mutations of reverse transcriptase gene in 102 HIV-1 infected patients living in China.
Abstract: In treated patients, two patterns of resistance associated mutations (RAMs) were observed: (1) K65R (9.8%), L74V (7.4%), M184V (7.4%), Q151M (5%), and thymidine analogue mutations (TAMs) (9.3%) including T215Y (5.5%), in patients who underwent ddI + d4T + NVP.
HIV mutation literature information.
PMID: 
2007
Journal of clinical microbiology
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