Discussion: The proportion that had complex NRTI resistance patterns, such as three or more TAMs or Q151M complex, was lower (5.5%) than another recent study of 38 children on ART from the same province where 39% had three or more TAMs despite a shorter duration (median = 2.8 yrs; IQR = 1.9- 2.3 yrs) on ART compared with our cohort (median = 3.3 yrs; IQR = 2.5-4.4 yrs).
Discussion: Whilst in most cases the mutations would be unlikely to significantly compromise a second-line regimen based on a ritonavir-boosted PI, five patients had complex mutation patterns (three or more TAMs or Q151M complex) that might substantially limit the future activity of the NRTI class of drugs.
Genotypic resistance profiles of HIV-2-treated patients in West Africa.
Abstract: We show here that four mutations (Y115F, M184V, M184I, and Q151M) in the dNTP-binding pocket of RT that had relatively small effects on the overall HIV-1 mutation rate (less than 3-fold compared to the wild type) significantly increased mutations at some specific positions in the lacZalpha reporter gene.
High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.
Result: The Q151M mutation was only detected in 2 ABC-exposed children (2.5%) and 6 d4T-exposed children (2.2%).
Emergence of drug resistance in human immunodeficiency virus type 1 infected patients from pune, India, at the end of 12 months of first line antiretroviral therapy initiation.
Abstract: However, direct associations of K70S with mutations within the Q151M-complex and of K70T with K65R were observed.
Abstract: In vitro phenotypic testing revealed only minor effects of K70R/S/T as single mutations, associated with Q151M and within the context of the Q151M-complex.
2014 Update of the drug resistance mutations in HIV-1.
Discussion: Q151M is the most important mutation in the complex (ie, the other mutations in the complex [A62V, V75I, F77L, and F116Y] in isolation may not reflect multidrug resistance).
Discussion: Tenofovir retains activity against the Q151M complex of mutations.
The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.
Introduction: Data from this study shows that while K65R was present in 82% of genomes without TAMs, and at low frequency in the presence of <3 TAMs; no sequences were identified with K65R, T215F/Y and >= 2 TAMs in the absence of the Q151M multi-drug resistant complex.
Introduction: Q151 is mutated to methionine (Q151M) in response to treatment with dideoxynucleoside analogs and usually occurs in combination with A62V, V75I, F77L, and F116Y mutations.
Introduction: The association of Q151M and other Q151M complex mutations with K65R,
A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses.
Result: The multi-NRTI resistance mutation Q151M occurred in two patients receiving both thymidine-analog and nonthymidine-analog containing regimens.
Discussion: Although A62V alone does not reduce NRTI susceptibility, it is an accessory utation that frequently co-occurs with K65R and Q151M, mutations responsible for multi-NRTI resistance.
HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.
PMID: 25141905
2014
Journal of the International AIDS Society
Abstract: There were 97/105 (92%) patients harbouring >= 1 RAMs at first-line failure, 39/105 with multi-NRTI RAMs: six with Q151M; 24 with >= 2 TAMs; and 32 with M184V+>= 1 TAM.
Abstract: Three patterns, including thymidine analogue mutations (TAMs), 69 Insertion (69Ins) and the Q151M complex, are associated with resistance to multiple-nucleoside reverse transcriptase inhibitors (NRTIs) and may compromise treatment options for second-line ART.
Abstract: We defined multi-NRTI RAMs as the presence of either Q151M; 69Ins; >= 2 TAMs; or M184V+>= 1 TAM.
Discussion: Six patients had Q151M, 24 had >=2 TAMs and 32 had
HIV mutation literature information.
PMID: 
2014
AIDS research and therapy
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