Drug-resistant mutation patterns in CRF01_AE cases that failed d4T+3TC+nevirapine fixed-dosed, combination treatment: Follow-up study from the Lampang cohort.
Abstract: The exposed group had predominantly thymidine analogue-related mutations, whereas the naive group had a higher prevalence of Q151M and K103N mutations.
Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations.
PMID: 20462946
2010
The Journal of antimicrobial chemotherapy
Method: We also examined the extent to which the 52 NNRTI-selected mutations covaried with mutations at 12 major nucleoside reverse transcriptase inhibitor (NRTI) resistance positions, including M41L, K65R, D67N, T69S_SS, K70E, K70R, L74V, L74I, V75M/T, Y115F, Q151M, M184V/I, L210W, T215F and T215Y.
Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.
PMID: 20649426
2010
The Journal of infectious diseases
Result: None of the samples had mutations at the following positions in HIV-1 reverse transcriptase that have been associated with acyclovir selection in vitro: V75I, T69N, W71X, R72X, Q151M, and M184V.
Proteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitors.
Abstract: The most deleterious mutations were K65R, Q151M, M184V/I, and T215Y/F, each of them decreasing susceptibility to most of the NRTIs.
Result: In contrast, some other mutations, such as Q151M exert similar influence on most of NRTIs (except on 3TC and FTC).
Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.
Result: HIV-1-associated thymidine analogue mutations (M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) were not found, with the exception of K70R, which was present in a strain from 1 patient (in conjunction with K65R, Q151M, and 219E, the latter of which is commonly present in wild-type HIV-2 in ARV therapy naive patients).
Result: Mutations K65R, Q151M, and M184V in RT have previously been shown to be associated with phenotypic NRTI resistance in HIV-2.
Result: The HIV-2 PMID: 19323038
2009
The Southeast Asian journal of tropical medicine and public health
Abstract: Thymidine analoque mutations, M184V/I, and Q151M were observed in 38%, 33%, and 5%.
Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance.
PMID: 19358668
2009
The Journal of infectious diseases
Abstract: Although thymidine analogue mutations had no effect on zidovudine sensitivity, the addition of Q151M together with K65R or M184V was sufficient for high-level resistance to both lamivudine and zidovudine in HIV-2, and the combination of K65R, Q151M, and M184V conferred classwide NRTI resistance.
Result: 3.1 +- 0.3 mumol/L, for Q151M and Q151M+3, respectively), indicating that A62V, F77L, and Y116F do not enhance AZT resistance in HIV-2.
Result: Although A62V, F77L, and
The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy.
Method: Factors associated with the emergence of K65R and K70E, pan-nucleoside resistance mutations (69 insertion, Q151M complex with K65R and K70E), and the presence of three or more TAM mutations were evaluated using logistic regression.
Method: Virus with 69 insertion or Q151M complex with K65R or
Table: Q151M
Discussion: The use of d4T in subtype C virus does not follow predictable patterns in the emergence of mutations and appears to be promiscuous in its ability to select for K65R and K70E (associated with TDF resistance), multiple TAM pathways, Q151M, and T69 insertions.
Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau.
Abstract: A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M.
Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya.
Abstract: The 3TC mutation M184V and the NNRTI mutation K103N were most frequent but also the multi-drug resistance Q151M and the broad NRTI cross-resistance K65R were observed.
Result: In one patient the multi-drug resistant Q151M mutation was seen and two patients carried virus with a K65R mutation, all three combined with V184M (Table S2; Additional File 2).
Discussion: The high percentage (62.5%) of patients with a combination of M184V mutations and at least one NNRTI resistance associated mutation, as well as the selection of the broad NRTI cross-res
HIV mutation literature information.
PMID: 
2010
Antiviral research
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