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 HIV mutation literature information.


  Mutation patterns of the reverse transcriptase genes in HIV-1 infected patients receiving combinations of nucleoside and non nucleoside inhibitors.
 PMID: 14522102       2003       International journal of antimicrobial agents
Abstract: Finally Q151M, the marker mutation able to confer resistance to all nucleoside analogues, was detected in seven patients with a viral load of between 1 x 10(4) and 9 x 10(4) HIV-1 RNA copies/ml.


  Antiretroviral therapy in HIV-2-infected patients: changes in plasma viral load, CD4+ cell counts, and drug resistance profiles of patients treated in Abidjan, Cote d'Ivoire.
 PMID: 14565609       2003       AIDS (London, England)
Abstract: Three patients had the multi-drug-resistant mutation, Q151M, two of whom showed reduced susceptibility to zidovudine, didanosine, stavudine and zalcitabine.


  Clinical, immunological and virological response to different antiretroviral regimens in a cohort of HIV-2-infected patients.
 PMID: 14565610       2003       AIDS (London, England)
Abstract: Development of mutations proved to be similar to that observed in HIV-1-infected patients, with the exception of a higher occurrence of the Q151M mutation within the reverse transcriptase gene.


  Long-term outcome of HIV-infected patients with multinucleoside-resistant genotypes.
 PMID: 14628280       2003       HIV clinical trials
Abstract: BACKGROUND: Multiple resistance to nucleoside analogs mediated by the Q151M complex and/or codon 67-69 inserts/deletions represents a growing problem among HIV-infected persons, most of whom have been exposed to sequential therapies for long periods of time.
Abstract: No differences were found when patients with Q151M and codon 67-69 rearrangements were compared.
Abstract: Twelve of them carried the Q151M complex and 9 harbored different codon 67-69 inserts.


  A review of HIV-1 resistance to the nucleoside and nucleotide inhibitors.
 PMID: 14754429       2003       Current drug targets. Infectious disorders
Abstract: There are several major genetic mutational patterns of resistance and cross-resistance that evolve with the NRTIs including the thymidine analog mutations M41L, D67N, K70R, L210W, T215Y, and K219Q/E/W, the non-thymidine mutations M184V, L74V, and K65R, and the multidrug resistant Q151M complex, as well as others.


  Nucleoside and nucleotide analogue reverse transcriptase inhibitors: a clinical review of antiretroviral resistance.
 PMID: 14760883       2003       Antiviral therapy
Abstract: Resistance to multiple nucleoside reverse transcriptase inhibitors (NRTIs) may result from several genotypically distinct pathways, including the Q151M (151 complex), the 69 insertion complex, two distinct thymidine analogue mutational pathways and the K65R mutation.


  Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails.
 PMID: 11782585       2002       Journal of acquired immune deficiency syndromes (1999)
Abstract: Similar analysis showed that recombinant viruses harboring mutations known to confer resistance to NRTIs (zidovudine, lamivudine, and abacavir) and NNRTIs (efavirenz and nevirapine) as well as the multidrug resistance-associated mutation Q151M and double codon insertions (SS and SG) were also susceptible to inhibition by DXG.


  Frequency of mutations conferring resistance to nucleoside reverse transcriptase inhibitors in human immunodeficiency virus type 1-infected patients in Korea.
 PMID: 11923351       2002       Journal of clinical microbiology
Abstract: However, Q151M was not detected.


  Drug resistance at low viraemia in HIV-1-infected patients with antiretroviral combination therapy.
 PMID: 11953470       2002       AIDS (London, England)
Abstract: One patient still had a VL of 300 copies/ml after 28 months, despite the presence of the multidrug-resistance Q151M mutation.


  Prevalence of HIV-1 polymerase gene mutations in pre-treated patients in Thailand.
 PMID: 12118466       2002       The Southeast Asian journal of tropical medicine and public health
Abstract: Zidovudine-resistant mutants: T215Y/F (36%), M41L (28%) and K70R (25.3%) were common; but mutations linked to didanosine (L74V) and multinucleoside-resistant genotypes (Q151M) were rarely recognized (2.4% and 3.6%, respectively).



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